Application of MPBT Assay for Multiplex Determination of Infectious Titers and for Selection of the Optimal Formulation for the Trivalent Novel Oral Poliovirus Vaccine.

Poliovirus Vaccine, Oral Poliovirus / genetics Humans Multiplex Polymerase Chain Reaction / methods Poliomyelitis / prevention & control Vaccines, Attenuated / immunology Reproducibility of Results Sensitivity and Specificity
OPV clinical trials multiplex titration nOPV poliovirus surveillance thermal stability vaccine formulation

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
14 Jun 2024
Historique:
received: 28 03 2024
revised: 11 06 2024
accepted: 12 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Recently, a multiplex PCR-based titration (MPBT) assay was developed for simultaneous determination of infectious titers of all three Sabin strains of the oral poliovirus vaccine (OPV) to replace the conventional CCID

Identifiants

DOI: 10.3390/v16060961 PMID: 38932253
pubmed: 38932253
pii: v16060961
doi: 10.3390/v16060961
pii:
doi:

Substances chimiques

Poliovirus Vaccine, Oral 0
Vaccines, Attenuated 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : This work was partially supported by funding from the Gates Foundation
ID : Investment ID INV-022260

Auteurs

Hasmik Manukyan (H)

Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Manjari Lal (M)

Center for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.
ORCID: 0000-0003-3574-9989

Changcheng Zhu (C)

Center for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.

Olga Singh (O)

Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Tsai-Lien Lin (TL)

Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Erman Tritama (E)

Research and Development Division, PT Bio Farma, Bandung 40161, Indonesia.

Konstantin Chumakov (K)

Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.

Shwu-Maan Lee (SM)

Center for Vaccine Innovation and Access, Program for Appropriate Technology in Health (PATH), Seattle, WA 98121, USA.
ORCID: 0000-0003-0819-0569

Majid Laassri (M)

Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA.
ORCID: 0000-0002-0110-5504

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins antipoliomyélitiques › Vaccin antipoliomyélitique oral › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Picornaviridae › Enterovirus › Entérovirus humain C › Poliovirus › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques d'amplification d'acides nucléiques › Réaction de polymérisation en chaîne › Réaction de polymérisation en chaine multiplex › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Maladies du système nerveux › Maladies neuromusculaires › Poliomyélite › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins atténués › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Application of MPBT Assay for Multiplex...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Sensibilité et spécificité › Application of MPBT Assay for Multiplex...