Evaluation of Remineralizing Capacity of Tricalcium Phosphate, Nano-Hydroxyapatite and Ozone Remineralizing Agents on the Artificial Carious Lesion.


Journal

Indian journal of dental research : official publication of Indian Society for Dental Research
ISSN: 1998-3603
Titre abrégé: Indian J Dent Res
Pays: India
ID NLM: 9202990

Informations de publication

Date de publication:
01 Jan 2024
Historique:
received: 10 09 2022
accepted: 03 11 2023
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: ppublish

Résumé

Dental caries is a dynamic process. By using therapeutic agents, early, noncavitated lesions and caries limited to the enamel can be stopped or even remineralized. For the remineralization of the initial carious lesion, many nonfluoridated remineralizing agents were investigated. An observational study to assess the remineralizing efficacy of tricalcium phosphate (TCP), nano-hydroxyapatite (nHAp) and ozone remineralizing agents on the artificial carious lesion. In this observational research, the artificial carious lesion was produced on extracted 40 premolar teeth. Later, remineralizing agents (Group A: nHAp, Group B: TCP, Group C: Ozone remineralizing agents, Group D: Control group (Deionized water) were used to remineralize demineralized teeth. Utilizing the Vickers Hardness Number, the level of demineralization and remineralization was assessed. Later these readings were statistically assessed using the Tukey's HSD (honestly significant difference) and ANOVA tests in SPSS version 21.0. The P value was set at 0.05 or less. After demineralization, there was a decrease in enamel microhardness values, with 32% in Group A, 26% in Group B, 22% in Group C, and 21% in Group D, respectively. From the baseline to demineralization, there was a statistically significant decrease in microhardness across all groups. After remineralization, Groups A, B, and C experienced an increase in microhardness while Group D experienced no changes. This showed that Group A had the highest remineralization percentage, followed by Group B and Group C. nHAp and TCP had the greater remineralizing ability, which can be used to manage initial carious lesions.

Sections du résumé

BACKGROUND BACKGROUND
Dental caries is a dynamic process. By using therapeutic agents, early, noncavitated lesions and caries limited to the enamel can be stopped or even remineralized. For the remineralization of the initial carious lesion, many nonfluoridated remineralizing agents were investigated.
OBJECTIVES OBJECTIVE
An observational study to assess the remineralizing efficacy of tricalcium phosphate (TCP), nano-hydroxyapatite (nHAp) and ozone remineralizing agents on the artificial carious lesion.
METHODOLOGY METHODS
In this observational research, the artificial carious lesion was produced on extracted 40 premolar teeth. Later, remineralizing agents (Group A: nHAp, Group B: TCP, Group C: Ozone remineralizing agents, Group D: Control group (Deionized water) were used to remineralize demineralized teeth. Utilizing the Vickers Hardness Number, the level of demineralization and remineralization was assessed. Later these readings were statistically assessed using the Tukey's HSD (honestly significant difference) and ANOVA tests in SPSS version 21.0. The P value was set at 0.05 or less.
RESULTS RESULTS
After demineralization, there was a decrease in enamel microhardness values, with 32% in Group A, 26% in Group B, 22% in Group C, and 21% in Group D, respectively. From the baseline to demineralization, there was a statistically significant decrease in microhardness across all groups. After remineralization, Groups A, B, and C experienced an increase in microhardness while Group D experienced no changes. This showed that Group A had the highest remineralization percentage, followed by Group B and Group C.
CONCLUSION CONCLUSIONS
nHAp and TCP had the greater remineralizing ability, which can be used to manage initial carious lesions.

Identifiants

pubmed: 38934756
doi: 10.4103/ijdr.ijdr_704_22
pii: 01363779-202435010-00018
doi:

Substances chimiques

Calcium Phosphates 0
tricalcium phosphate K4C08XP666
Durapatite 91D9GV0Z28
Ozone 66H7ZZK23N
Cariostatic Agents 0

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

84-87

Informations de copyright

Copyright © 2024 Copyright: © 2024 Indian Journal of Dental Research.

Références

Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, et al. Demineralization–remineralization dynamics in teeth and bone. Int J Nanomedicine 2016; 11: 4743–63.
Duraisamy Y, Elizabeth Chaly P, Priyadarshni V, Mohammed J, Vaishnavi Evaluation of remineralization potential of theobromine on human enamel surfaces- an in vitro study. Inter J Scientific Res (IJSR) 2017; 6: 435–8.
Daokar SG, Kagne KS, Pawar KS, Wahane KD, Thorat TV, Mahakale CR, et al. The comparative evaluation of the effects of antioxidants pretreatment on remineralization of demineralized dentin-In vitro study. J Interdiscip Dentistry 2020; 10: 67–73.
Prasad LK, Moinuddin K, Nagamaheshwari X, Udaykumar P, Shekar K, Kaushik M Comparison of remineralizing effect of organic and inorganic fluoride by evaluation of microhardness and quantitative analysis of calcium and phosphorus ratio on enamel surface: An in-vitro study. Int J Dent Mater 2020; 2: 75–81.
Savas S, Kavrìk F, Kucukyìlmaz E Evaluation of the remineralization capacity of CPP-ACP containing fluoride varnish by different quantitative methods. J Appl Oral Sci 2016; 24: 198–203.
Joshi C, Gohil U, Parekh V, Joshi S Comparative evaluation of the remineralizing potential of commercially available agents on artificially demineralized human enamel: An in vitro study. Contemp Clin Dent 2019; 10: 605–13.
Chokshi K, Chokshi A, Sebastian SS, Zaheer A, Mohan S, Dhanya RS Newer nonfluoride remineralizing agents: An insight. Int J Oral Care Res 2016; 4: 291–6.
Balakrishnan A, Jonathan R, Benin P, Kumar A Evaluation to determine the caries remineralization potential of three dentifrices: An in vitro study. J Conserv Dent 2013; 16: 375–9.
Karawia IM, Mohamed OS The effect of ozone gas using different remineralizing materials on non-cavitated caries-like lesions in permanent teeth. OHDM 2017; 16: 1–5.
Reddy S A, Reddy N, Dinapadu S, Reddy M, Pasari S Role of ozone therapy in minimal intervention dentistry and endodontics-A review. J Int Oral Health 2013; 5: 102–8.
Babaji P, Melkundi M, Bhagwat P, Mehta V An in vitro evaluation of remineralizing capacity of self-assembling peptide (SAP) P11-4 and casein phosphopeptides-amorphous calcium phosphate (CPP-ACP) on artificial enamel. Pesqui. Bras. Odontopediatria Clín Integr 2019; 19: e4504.
Sindhura V, Uloopi KS, Vinay C, Chandrasekhar R Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro. J Indian Soc Pedod Prev Dent 2018; 36: 352–6.
Deswal R, Kukreja N, Chhabra S, Trivedi S, Sharma A, Thakur A Comparative assessment of enamel microhardness using various remineralising agents on artificially demineralized human enamel. Cureus 2022; 14: e30281.
Jagga U, Paul U, Padmanabhan V, Kashyap A, Guram G, Keswani K Comparative evaluation of remineralizing effect of novamin and tricalcium phosphate on artificial caries: An in vitro study. J Contemp Dent Pract 2018; 19: 109–12.
Lata S, Varghese NO, Varughese JM Remineralization potential of fluoride and amorphous calcium phosphate-casein phospho peptide on enamel lesions: An in vitro comparative evaluation. J Conserv Dent 2010; 13: 42–6.
Patil N, Choudhari S, Kulkarni S, Joshi SR Comparative evaluation of remineralizing potential of three agents on artificially demineralized human enamel: An in vitro study. J Conserv Dent 2013; 16: 116–20.
Rawal K, Manne RK, Gandikota CS, Shivaram N Evaluation of efficacy of various remineralizing agents on artificially demineralized human enamel –An in-vitro study. J Contemp Orthod 2023; 7: 17–23.
Grocholewicz K, Matkowska-Cichocka G, Makowiecki P, Droździk A, Ey-Chmielewska H, Dziewulska A, et al. Effect of nano-hydroxyapatite and ozone on approximal initial caries: A randomized clinical trial. Sci Rep 2020; 10: 11192.
Alhamed M, Almalki F, Alselami A, Alotaibi T, Elkwatehy W Effect of different remineralizing agents on the initial carious lesions – A comparative study. Saudi Dent J 2020; 32: 390–5.
Juntavee A, Juntavee N, Hirunmoon P Remineralization potential of nanohydroxyapatite toothpaste comparedwith tricalcium phosphate and fluoride toothpaste on artificial carious lesions. Int J Dent 2021 2021 5588832.

Auteurs

Shahzad Ali Shah (SA)

Department of Restorative Dentistry, College of Dentistry, Ar Rass College of Applied Health Sciences, Qassim University, Saudi Arabia.

Mehak Sharma (M)

Department of Conservative Dentistry and Endodontics, Swami Devi Dyal Hospital and Dental College, Panchakula, Haryana, India.

Prabu Mahin Syed Ismail (PMS)

Department of Restorative Dentistry, College of Dentistry, Ar Rass College of Applied Health Sciences, Qassim University, Saudi Arabia.

Prashant Babaji (P)

Department of Pediatric Dentistry, Sharavathi Dental College and Hospital, Shimogaa, Karnataka, India.

Azhar Mohammed (A)

Department of Orthodontics and Dentofacial Orthopaedics, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences, Mangalore, Karnataka, India.

Bhavna Malik (B)

Department of Dentistry, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, India.

Ananyo Mandal (A)

Department of Conservative Dentistry and Endodontics, Kusum Devi Sunderlal Dugar Jain Dental College, Kolkata, West Bengal, India.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH