High-resolution ion mobility based on traveling wave structures for lossless ion manipulation resolves hidden lipid features.
High-resolution ion mobility-mass spectrometry
Ion mobility-mass spectrometry
Lipid structure
Lipidomics
Structures for lossless ion manipulation
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
27 Jun 2024
27 Jun 2024
Historique:
received:
11
04
2024
accepted:
29
05
2024
revised:
24
05
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
aheadofprint
Résumé
High-resolution ion mobility (resolving power > 200) coupled with mass spectrometry (MS) is a powerful analytical tool for resolving isobars and isomers in complex samples. High-resolution ion mobility is capable of discerning additional structurally distinct features, which are not observed with conventional resolving power ion mobility (IM, resolving power ~ 50) techniques such as traveling wave IM and drift tube ion mobility (DTIM). DTIM in particular is considered to be the "gold standard" IM technique since collision cross section (CCS) values are directly obtained through a first-principles relationship, whereas traveling wave IM techniques require an additional calibration strategy to determine accurate CCS values. In this study, we aim to evaluate the separation capabilities of a traveling wave ion mobility structures for lossless ion manipulation platform integrated with mass spectrometry analysis (SLIM IM-MS) for both lipid isomer standards and complex lipid samples. A cross-platform investigation of seven subclass-specific lipid extracts examined by both DTIM-MS and SLIM IM-MS showed additional features were observed for all lipid extracts when examined under high resolving power IM conditions, with the number of CCS-aligned features that resolve into additional peaks from DTIM-MS to SLIM IM-MS analysis varying between 5 and 50%, depending on the specific lipid sub-class investigated. Lipid CCS values are obtained from SLIM IM (
Identifiants
pubmed: 38935144
doi: 10.1007/s00216-024-05385-8
pii: 10.1007/s00216-024-05385-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Department of Energy
ID : DE-SC0022207
Informations de copyright
© 2024. The Author(s).
Références
Hornemann T. Lipidomics in biomarker research. Handb Exp Pharmacol. 2022;270:493–510.
doi: 10.1007/164_2021_517
pubmed: 34409495
Ekroos K, Lavrynenko O, Titz B, Pater C, Hoeng J, Ivanov N. Lipid-based biomarkers for CVD, COPD, and aging – a translational perspective. Prog Lipid Res. 2020;78: 101030.
doi: 10.1016/j.plipres.2020.101030
pubmed: 32339553
May JC, McLean JA. Advanced multidimensional separations in mass spectrometry: navigating the big data deluge. Annu Rev Anal Chem. 2016;9(1):387–409.
doi: 10.1146/annurev-anchem-071015-041734
Dodds JN, Baker ES. Ion mobility spectrometry: fundamental concepts, instrumentation, applications, and the road ahead. J Am Soc Mass Spectrom. 2019;30(11):2185–95.
doi: 10.1007/s13361-019-02288-2
pubmed: 31493234
pmcid: 6832852
Dodds JN, May JC, McLean JA. Correlating resolving power, resolution, and collision cross section: unifying crossplatform assessment of separation efficiency in ion mobility spectrometry. Anal Chem. 2017;89(22):12176–84.
doi: 10.1021/acs.analchem.7b02827
pubmed: 29039942
pmcid: 5744666
May JC, Dodds JN, Kurulugama RT, Stafford GC, Fjeldsted JC, McLean JA. Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer. Analyst. 2015;140(20):6824–33.
doi: 10.1039/C5AN00923E
pubmed: 26191544
pmcid: 4586486
Giles K, Ujma J, Wildgoose J, Pringle S, Richardson K, Langridge D, Green M. A cyclic ion mobility-mass spectrometry system. Anal Chem. 2019;91(13):8564–73.
doi: 10.1021/acs.analchem.9b01838
pubmed: 31141659
Miller SA, Dit Fouque KJ, Ridgeway ME, Park MA, Fernandez-Lima F. Trapped ion mobility spectrometry, ultraviolet photodissociation and TOF mass spectrometry for gas-phase peptide isobars/ isomers/conformers discrimination. J Am Soc Mass Spectrom. 2022;33(7):1267–75.
doi: 10.1021/jasms.2c00091
pubmed: 35658468
pmcid: 9262853
May JC, Leaptrot KL, Rose BS, Wormwood Moser KL, Deng L, Maxon L, DeBord D, McLean JA. Resolving power and collision cross section measurement accuracy of a prototype high resolution ion mobility platform incorporating structures for lossless ion manipulation. J Am Soc Mass Spectrom. 2021;32(4):1126–37.
doi: 10.1021/jasms.1c00056
pubmed: 33734709
pmcid: 9296130
Bansal P, Yatsyna V, AbiKhodr AH, Warnke S, Ben Faleh A, Yalovenko N, Wysocki VH, Rizzo TR. Using SLIM-Based IMS-IMS together with cryogenic infrared spectroscopy for glycan analysis. Anal Chem. 2020;92(13):9079–85.
doi: 10.1021/acs.analchem.0c01265
pubmed: 32456419
pmcid: 7349563
Wormwood Moser KL, Van Aken G, DeBord D, Hatcher NG, Maxon L, Sherman M, Yao L, Ekroos K. High-defined quantitative snapshots of the ganglioside lipidome using high resolution ion mobility SLIM assisted shotgun lipidomics. Anal Chim Acta. 2021;1146:77–87.
doi: 10.1016/j.aca.2020.12.022
pubmed: 33461722
Kedia K, Harris R, Ekroos K, Moser KW, DeBord D, Tiberi P, Goracci L, Zhang NR, Wang W, Spellman DS, Bateman K. Investigating performance of the SLIM-Based high resolution ion mobility platform for separation of isomeric phosphatidylcholine species. J Am Soc Mass Spectrom. 2023;34(10):2176–86.
doi: 10.1021/jasms.3c00157
pubmed: 37703523
Dodds JN, May JC, McLean JA. Investigation of the complete suite of the leucine and isoleucine isomers: towards prediction of ion mobility separation capabilities. Anal Chem. 2017;89(1):952–9.
doi: 10.1021/acs.analchem.6b04171
pubmed: 28029037
Deng L, Webb IK, Garimella SVB, Hamid AM, Zheng X, Norheim RV, Prost SA, Anderson GA, Sandoval JA, Baker ES, Ibrahim YM, Smith RD. Serpentine ultralong path with extended routing (SUPER) high resolution traveling wave ion mobility-MS using structures for lossless ion manipulations. Anal Chem. 2017;89(8):4628–34.
doi: 10.1021/acs.analchem.7b00185
pubmed: 28332832
pmcid: 5627996
Kyle JE, Zhang X, Weitz KK, Monroe ME, Ibrahim YM, Moore RJ, Cha J, Sun X, Lovelace ES, Wagoner J, Polyak SJ, Metz TO, Dey SK, Smith RD, Burnum-Johnson KE, Baker ES. Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry. Analyst. 2016;141:1649–59.
doi: 10.1039/C5AN02062J
pubmed: 26734689
pmcid: 4764491
Leaptrot KL, May JC, Dodds JN, McLean JA. Ion mobility conformational lipid atlas for high confidence lipidomics. Nat Commun. 2019;10(1):985.
doi: 10.1038/s41467-019-08897-5
pubmed: 30816114
pmcid: 6395675
May JC, Morris CB, McLean JA. Ion mobility collision cross section compendium. Anal Chem. 2017;89(2):1032–44.
doi: 10.1021/acs.analchem.6b04905
pubmed: 28035808
Nichols CM, May JC, Sherrod SD, McLean JA. Automated flow injection method for the high precision determination of drift tube ion mobility collision cross sections. Analyst. 2018;143:1556–9.
doi: 10.1039/C8AN00056E
pubmed: 29541727
pmcid: 5869168
Stow SM, Causon TJ, Zheng X, Kurulugama RT, Mairinger T, May JC, Rennie EE, Baker ES, Smith RD, McLean JA, Hann S, Fjeldsted JC. An interlaboratory evaluation of drift tube ion mobility−mass spectrometry collision cross section measurements. Anal Chem. 2017;89(17):9048–55.
doi: 10.1021/acs.analchem.7b01729
pubmed: 28763190
pmcid: 5744684
Rose BS, May JC, Reardon AR, McLean JA. Collision cross-section calibration strategy for lipid measurements in SLIM-Based high-resolution ion mobility. J Am Soc Mass Spectrom. 2022;33(7):1229–37.
doi: 10.1021/jasms.2c00067
pubmed: 35653638
pmcid: 9516683
McLean Research Group. Unified CCS Compendium. https://mcleanresearchgroup.shinyapps.io/CCS-Compendium/ . Accessed 11 Apr 2024.
Picache JA, Rose BS, Balinski A, Leaptrot KL, Sherrod SD, May JC, McLean JA. Collision cross section compendium to annotate and predict multi-omic compound identities. Chem Sci. 2019;10(4):983–93.
doi: 10.1039/C8SC04396E
pubmed: 30774892
Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH Jr, Murphy RC, Raetz CRH, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA. A comprehensive classification system for lipids. J Lipid Res. 2005;46(5):839–61.
doi: 10.1194/jlr.E400004-JLR200
pubmed: 15722563
Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CRH, Shimizu T, Spener F, van Meer G, Wakelam MJO, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res. 2009;50:S9-14.
doi: 10.1194/jlr.R800095-JLR200
pubmed: 19098281
pmcid: 2674711
Hines KM, May JC, McLean JA, Xu L. Evaluation of collision cross section calibrants for structural analysis of lipids by traveling wave ion mobility-mass spectrometry. Anal Chem. 2016;88(14):7329–36.
doi: 10.1021/acs.analchem.6b01728
pubmed: 27321977
pmcid: 4955523
Dit Fouque KJ, Ramirez CE, Lewis RL, Koelmel JP, Garrett TJ, Yost RA, Fernandez-Lima F. Effective liquid chromatography-trapped ion mobility spectrometry-mass spectrometry separation of isomeric lipid species. Anal Chem. 2019;91(8):5021–7.
doi: 10.1021/acs.analchem.8b04979
Harris RA, May JC, Stinson CA, Xia Y, McLean JA. Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry. Anal Chem. 2018;90(3):1915–24.
doi: 10.1021/acs.analchem.7b04007
pubmed: 29341601
pmcid: 7331456
Brown SHJ, Mitchell TW, Blanksby SJ. Analysis of unsaturated lipids by ozone-induced dissociation. Biochim Biophys Acta. 2011;1811:807–17.
doi: 10.1016/j.bbalip.2011.04.015
pubmed: 21571093
Nichols CM, Dodds JN, Rose BS, Picache JA, Morris CB, Codreanu SG, May JC, Sherrod SD, McLean JA. Untargeted molecular discovery in primary metabolism: collision cross section as a molecular descriptor in ion mobility-mass spectrometry. Anal Chem. 2018;90(24):14484–92.
doi: 10.1021/acs.analchem.8b04322
pubmed: 30449086
pmcid: 6819070