GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans.

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
27 Jun 2024
Historique:
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: aheadofprint

Résumé

GLP-1 receptor agonists (GLP-1RAs) are effective anti-obesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to obese patients and observed heightened sense of preingestive satiation. Analysis of human and mouse brain samples pinpointed GLP-1R neurons in the dorsomedial hypothalamus (DMH) as candidates for encoding preingestive satiation. Optogenetic manipulation of DMH

Identifiants

DOI: 10.1126/science.adj2537 PMID: 38935778
pubmed: 38935778
doi: 10.1126/science.adj2537
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj2537

Auteurs

Kyu Sik Kim (KS)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0000-0001-9983-8759

Joon Seok Park (JS)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0000-0002-1901-8097

Eunsang Hwang (E)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-4298-5368

Min Jung Park (MJ)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
ORCID: 0000-0003-1638-3491

Hwa Yun Shin (HY)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0009-0007-1929-938X

Young Hee Lee (YH)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0000-0003-0633-9841

Kyung Min Kim (KM)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.

Laurent Gautron (L)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0003-3609-7441

Elizabeth Godschall (E)

Department of Biology, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0002-9719-5048

Bryan Portillo (B)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Kyle Grose (K)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Sang-Ho Jung (SH)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0000-0001-5886-8855

So Lin Baek (SL)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.

Young Hyun Yun (YH)

Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0000-0002-2747-9459

Doyeon Lee (D)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.
ORCID: 0009-0001-4883-0404

Eunseong Kim (E)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
ORCID: 0009-0008-5107-6634

Jason Ajwani (J)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Seong Ho Yoo (SH)

Department of Forensic Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Seoul, Republic of Korea.
ORCID: 0000-0001-5294-0596

Ali D Güler (AD)

Department of Biology, University of Virginia, Charlottesville, VA, USA.
ORCID: 0000-0001-8218-850X

Kevin W Williams (KW)

Center for Hypothalamic Research, Department of Internal Medicine, Peter O'Donnell Jr. Brain Institute, UT Southwestern Medical Center, Dallas, TX, USA.
ORCID: 0000-0002-8434-8658

Hyung Jin Choi (HJ)

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Department of Anatomy and Cell Biology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Neuroscience Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea.
Wide River Institute of Immunology, Seoul National University, 101 Dabyeonbat-gil, Hwachon-myeon, Gangwon-do 25159, Republic of Korea.
Department of Brain and Cognitive Sciences, Seoul National University, Seoul, Republic of Korea.
ORCID: 0000-0003-0593-6978

Classifications MeSH