The extent of postpartum cardiac reverse remodeling is reflected in urine proteome.
Cardiovascular reverse remodeling
Cardiovascular risk factor
Hemodynamic overload
Pregnancy
Proteome
Urine
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 06 2024
27 06 2024
Historique:
received:
26
01
2024
accepted:
21
06
2024
medline:
28
6
2024
pubmed:
28
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
The association of postpartum cardiac reverse remodeling (RR) with urinary proteome, particularly in pregnant women with cardiovascular (CV) risk factors who show long-term increased risk of cardiovascular disease and mortality is unknown. We aim to profile the urinary proteome in pregnant women with/without CV risk factors to identify proteins associated with postpartum RR. Our study included a prospective cohort of 32 healthy and 27 obese and/or hypertensive and/or diabetic pregnant women who underwent transthoracic echocardiography, pulse-wave-velocity, and urine collection at the 3rd trimester and 6 months postpartum. Shotgun HPLC-MS/MS profiled proteins. Generalized linear mixed-effects models were used to identify associations between urinary proteins and left ventricle mass (LVM), a surrogate of RR. An increase in arterial stiffness was documented from 3rd trimester to 6 months after delivery, being significantly elevated in women with CV risk factors. In addition, the presence of at least one CV risk factor was associated with worse LVM RR. We identified 6 and 11 proteins associated with high and low LVM regression, respectively. These proteins were functionally linked with insulin-like growth factor (IGF) transport and uptake regulation by IGF binding-proteins, platelet activation, signaling and aggregation and the immune system's activity. The concentration of IGF-1 in urine samples was associated with low LVM regression after delivery. Urinary proteome showed a predicting potential for identifying pregnant women with incomplete postpartum RR.
Identifiants
pubmed: 38937573
doi: 10.1038/s41598-024-65612-1
pii: 10.1038/s41598-024-65612-1
doi:
Substances chimiques
Proteome
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14815Subventions
Organisme : Horizon 2020 program of the European Union
ID : EPIC-XS, project number 318
Organisme : Sociedade Portuguesa de Cardiologia
ID : Bolsa de Estudo João Porto
Organisme : Sociedade Portuguesa de Cardiologia
ID : Prémio Saúde Cardiovascular da Mulher
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/138925/2018
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIDP/00051/2020
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/144982/2019
Organisme : Fundação para a Ciência e a Tecnologia
ID : UIBD1523062021
Organisme : Fundação para a Ciência e a Tecnologia
ID : RTP Maratona da Saúde 2017
Organisme : European Regional Development Fund
ID : NORTE-01-0145-FEDER-000039
Informations de copyright
© 2024. The Author(s).
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