Control and recalibration of path integration in place cells using optic flow.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
27 Jun 2024
27 Jun 2024
Historique:
received:
28
06
2022
accepted:
13
05
2024
medline:
28
6
2024
pubmed:
28
6
2024
entrez:
27
6
2024
Statut:
aheadofprint
Résumé
Hippocampal place cells are influenced by both self-motion (idiothetic) signals and external sensory landmarks as an animal navigates its environment. To continuously update a position signal on an internal 'cognitive map', the hippocampal system integrates self-motion signals over time, a process that relies on a finely calibrated path integration gain that relates movement in physical space to movement on the cognitive map. It is unclear whether idiothetic cues alone, such as optic flow, exert sufficient influence on the cognitive map to enable recalibration of path integration, or if polarizing position information provided by landmarks is essential for this recalibration. Here, we demonstrate both recalibration of path integration gain and systematic control of place fields by pure optic flow information in freely moving rats. These findings demonstrate that the brain continuously rebalances the influence of conflicting idiothetic cues to fine-tune the neural dynamics of path integration, and that this recalibration process does not require a top-down, unambiguous position signal from landmarks.
Identifiants
pubmed: 38937582
doi: 10.1038/s41593-024-01681-9
pii: 10.1038/s41593-024-01681-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01NS102537
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01NS102537
Organisme : United States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Office (ARO)
ID : W911NF1810327
Organisme : United States Department of Defense | United States Army | U.S. Army Research, Development and Engineering Command | Army Research Office (ARO)
ID : W911NF1810327
Organisme : Johns Hopkins University (Johns Hopkins)
ID : Discovery
Organisme : Johns Hopkins University (Johns Hopkins)
ID : Discovery
Organisme : U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER)
ID : R01NS102537
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
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