Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior.
Aedes aegypti
Host-seeking
Mosquito
Neuropeptide Y
Small-molecule agonist
Structure-guided design
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
28 Jun 2024
28 Jun 2024
Historique:
received:
25
03
2024
accepted:
09
06
2024
medline:
28
6
2024
pubmed:
28
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until eggs are laid. Neuropeptide Y-like receptor 7 (NPYLR7) plays a role in endogenous host-seeking suppression and previous work identified small-molecule NPYLR7 agonists that inhibit host-seeking and blood-feeding when fed to mosquitoes at high micromolar doses. Using structure-activity relationship analysis and structure-guided design we synthesized 128 compounds with similarity to known NPYLR7 agonists. Although in vitro potency (EC Exogenous activation of NPYLR7 represents an innovative vector control strategy to block mosquito biting behavior and prevent mosquito-human host interactions that lead to pathogen transmission.
Sections du résumé
BACKGROUND
BACKGROUND
Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until eggs are laid. Neuropeptide Y-like receptor 7 (NPYLR7) plays a role in endogenous host-seeking suppression and previous work identified small-molecule NPYLR7 agonists that inhibit host-seeking and blood-feeding when fed to mosquitoes at high micromolar doses.
METHODS
METHODS
Using structure-activity relationship analysis and structure-guided design we synthesized 128 compounds with similarity to known NPYLR7 agonists.
RESULTS
RESULTS
Although in vitro potency (EC
CONCLUSIONS
CONCLUSIONS
Exogenous activation of NPYLR7 represents an innovative vector control strategy to block mosquito biting behavior and prevent mosquito-human host interactions that lead to pathogen transmission.
Identifiants
pubmed: 38937807
doi: 10.1186/s13071-024-06347-w
pii: 10.1186/s13071-024-06347-w
doi:
Substances chimiques
Receptors, Neuropeptide Y
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
276Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM137888
Pays : United States
Organisme : The Arnold and Mabel Beckman Foundation
ID : Beckman Young Investigator Award
Organisme : The Pew Foundation
ID : Pew Biomedical Scholars Award
Organisme : Esther A. and Joseph Klingenstein Fund
ID : Klingenstein-Simons Fellowship Award in Neuroscience
Informations de copyright
© 2024. The Author(s).
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