Cancer metastasis through the lymphatic versus blood vessels.

Cancer metastasis Lymphatic and blood vessels

Journal

Clinical & experimental metastasis
ISSN: 1573-7276
Titre abrégé: Clin Exp Metastasis
Pays: Netherlands
ID NLM: 8409970

Informations de publication

Date de publication:
28 Jun 2024
Historique:
received: 26 01 2024
accepted: 10 04 2024
medline: 28 6 2024
pubmed: 28 6 2024
entrez: 28 6 2024
Statut: aheadofprint

Résumé

Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is still under intense study. In this review article, we follow the journey of cancer cells metastasizing to the sentinel lymph nodes and beyond to the distant sites. We emphasize cancer heterogeneity and microenvironment as major determinants of cancer metastasis. Multiple molecules have been found to be associated with the complicated process of metastasis. Based on the large sentinel lymph node data, it is reasonable to conclude that cancer cells may metastasize through the blood vessels in some cases but in most cases, they use the sentinel lymph nodes as the major gateway to enter the circulation to distant sites.

Identifiants

DOI: 10.1007/s10585-024-10288-0 PMID: 38940900
pubmed: 38940900
doi: 10.1007/s10585-024-10288-0
pii: 10.1007/s10585-024-10288-0
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Stanley P Leong (SP)

California Pacific Medical Center and Research Institute, University of California School of Medicine, San Francisco, USA. Stanley.Leong@sutterhealth.org.

Marlys H Witte (MH)

Department of Surgery, Neurosurgery and Pediatrics, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.

Classifications MeSH