Intraoral CD30+ T-Cell Lymphoproliferative Disorder with Lymphomatoid Papulosis Type C Features Mimics Lymphoma Histopathologically and Immunohistochemically.
Anaplastic large cell lymphoma
Differential diagnosis
Lymphomatoid papulosis type C
Lymphoproliferative disorder
Oral cavity
Journal
Head and neck pathology
ISSN: 1936-0568
Titre abrégé: Head Neck Pathol
Pays: United States
ID NLM: 101304010
Informations de publication
Date de publication:
28 Jun 2024
28 Jun 2024
Historique:
received:
07
05
2024
accepted:
01
06
2024
medline:
28
6
2024
pubmed:
28
6
2024
entrez:
28
6
2024
Statut:
epublish
Résumé
Previous studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology. A 60-year-old male was referred for a one-month history of a tongue ulcer. Microscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed. We present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C.
Sections du résumé
BACKGROUND
BACKGROUND
Previous studies have shown that at least a of intraoral eosinophilic ulcer is best classified as a CD30 + T-cell lymphoproliferative disorder (LPD), with histopathology reminiscent of lymphomatoid papulosis (LyP) of the skin. Microscopically, a mixed population of inflammatory cells, often including eosinophils and varying numbers of atypical lymphoid cells, frequently expressing CD30, is typical for LyP, whose clinicopathological spectrum includes type A, B, C, D, E, and LyP with DUSP22/IRF4 rearrangement. To date, about 27 intraoral LyP cases have been reported. Of them, 7 cases were diagnosed as LyP type C, which is frequently confused with anaplastic large cell lymphoma (ALCL) on histopathology.
METHODS
METHODS
A 60-year-old male was referred for a one-month history of a tongue ulcer.
RESULTS
RESULTS
Microscopy showed numerous subepithelial atypical large lymphoid cells, which expressed CD4 (with partial loss of CD3, CD5, and CD7), CD8 (few cells), CD30 (about 50%, in non-diffuse pattern with size variability), TIA-1, and Ki-67 (85%), without staining for CD56, ALK, LMP1, and EBER1/2, concerning for a diagnosis of ALCL. However, after three weeks, the lesion completely healed.
CONCLUSION
CONCLUSIONS
We present here a rare case of intraoral CD30+ T-cell LPD that we believe is the oral counterpart of cutaneous LyP type C.
Identifiants
pubmed: 38941041
doi: 10.1007/s12105-024-01664-z
pii: 10.1007/s12105-024-01664-z
doi:
Substances chimiques
Ki-1 Antigen
0
Biomarkers, Tumor
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
60Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : (2016/11419-0; 2022/07479-9 and 2022/12760-9)
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : (304241/2021-0)
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Setti G, Martella E, Mancini C, Vescovi P, Magnoni C, Bellini P et al (2019) Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case. BMC Oral Health 19:186
doi: 10.1186/s12903-019-0875-5
pubmed: 31416455
pmcid: 6694504
Salisbury CL, Budnick SD, Li S (2009) T-cell receptor gene rearrangement and CD30 immunoreactivity in traumatic ulcerative granuloma with stromal eosinophilia of the oral cavity. Am J Clin Pathol 132:722–727
doi: 10.1309/AJCPX3S5MSOVVLOP
pubmed: 19846813
Schwartz Z, Coleman M, Toyohara JP, Freedman PD, Magro CM (2017) Oral lymphomatoid papulosis type C: a diagnostic pitfall, often confused with T-cell lymphoma. Ann Diagn Pathol 31:50–55
doi: 10.1016/j.anndiagpath.2017.06.003
pubmed: 29146059
Ficarra G, Prignano F, Romagnoli P (1997) Traumatic eosinophilic granuloma of the oral mucosa: a CD30+(Ki-1) lymphoproliferative disorder? Oral Oncol 33:375–379
doi: 10.1016/S1368-8375(97)00014-6
pubmed: 9415340
Segura S, Romero D, Mascaró JM Jr, Colomo L, Ferrando J, Estrach T (2006) Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30 + lymphoproliferative disorders. Br J Dermatol 155:460–463
doi: 10.1111/j.1365-2133.2006.07331.x
pubmed: 16882190
Bordignon NC, Correia-Neto IJ, Gondak R, de Albuquerque-Júnior RL (2024) Traumatic ulcerative granuloma with stromal eosinophilia mimicking a squamous cell carcinoma. J Clin Exp Dent 16:e377–e382
doi: 10.4317/jced.61322
pubmed: 38600925
pmcid: 11003278
Silveira HA, Ragusa Silva PV, Pimentel BG, Nogueira GM, Chahud F, Brunaldi MO et al (2023) Lymphomatoid papulosis type e affecting the palate: a detailed case report and review of literature. Am J Dermatopathol 45:326–329
doi: 10.1097/DAD.0000000000002405
pubmed: 36939130
Corail DR, Mondoloni M, Calvo AS et al (2022) Oral manifestation of lymphomatoid papulosis: systematic review. J Oral Med Oral Surg 28:30–42
doi: 10.1051/mbcb/2021043
Kempf W, Jansen PM, Kadin M et al T-cell and NK-cell lymphoid proliferations and lymphomas. In: WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [Internet]. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11)
Yoon HJ, Choe JY, Jeon YK (2015) Mucosal CD30-Positive T-Cell lymphoproliferative disorder arising in the oral cavity following Dental implants: Report of the First Case. Int J Surg Pathol 23:656–661
doi: 10.1177/1066896915599059
pubmed: 26261101
Ferrisse TM, Almeida LY, Silveira HA, de Oliveira AB, Bufalino A, León JE (2019) Benign atypical intralymphatic CD30 + lymphoid proliferation with activated regulatory T-cell phenotype in the oral cavity. J Cutan Pathol 46:891–894
doi: 10.1111/cup.13535
pubmed: 31237706
Kempf W (2006) CD30 + lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol 33(Suppl 1):58–70
doi: 10.1111/j.0303-6987.2006.00548.x
pubmed: 16412214
Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH et al (2019) The 2018 update of the WHOEORTC classification for primary cutaneous lymphomas. Blood 133:1703–1714
doi: 10.1182/blood-2018-11-881268
pubmed: 30635287
pmcid: 6473500
de Andrade BAB, Fontes MD, Roza ALOC, Vargas PA, Agostini M, Canedo NHS et al (2020) Anaplastic large cell lymphoma with oral manifestation: a series of four cases and literature review. Head Neck Pathol 14:991–1000
doi: 10.1007/s12105-020-01176-6
pubmed: 32440751
pmcid: 7669931
Parkhi M, Singh C, Malhotra P, Bal A (2021) Non-mammary implant associated anaplastic large cell lymphoma. Pathology 53:282–285
doi: 10.1016/j.pathol.2020.06.022
pubmed: 32967772