Ex-Vivo

astrocyte ex-vivo NMR metabolomics neuroinflammation stable isotope tracing tumor necrosis factor

Journal

Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775

Informations de publication

Date de publication:
29 Jun 2024
Historique:
medline: 29 6 2024
pubmed: 29 6 2024
entrez: 29 6 2024
Statut: aheadofprint

Résumé

Tumor necrosis factor (TNF) has well-established roles in neuroinflammatory disorders, but the effect of TNF on the biochemistry of brain cells remains poorly understood. Here, we microinjected TNF into the brain to study its impact on glial and neuronal metabolism (glycolysis, pentose phosphate pathway, citric acid cycle, pyruvate dehydrogenase, and pyruvate carboxylase pathways) using

Identifiants

DOI: 10.1021/acs.jproteome.4c00035 PMID: 38943617
pubmed: 38943617
doi: 10.1021/acs.jproteome.4c00035
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Daniel Radford-Smith (D)

Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.
Pharmacology Department, University of Oxford, Oxford OX1 3QT, U.K.

Tang T Ng (TT)

Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.

Abi G Yates (AG)

Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.
Pharmacology Department, University of Oxford, Oxford OX1 3QT, U.K.

Isobel Dunstan (I)

Pharmacology Department, University of Oxford, Oxford OX1 3QT, U.K.

Timothy D W Claridge (TDW)

Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.

Daniel C Anthony (DC)

Pharmacology Department, University of Oxford, Oxford OX1 3QT, U.K.

Fay Probert (F)

Department of Chemistry, University of Oxford, Oxford OX1 3TA, U.K.
ORCID: 0000-0002-8580-2023

Classifications MeSH