Subchronic Oral Toxicity Study of the Synbiotic Mulberry in Male and Female Wistar rats.

Mulberry NOAEL Probiotics Subchronic toxicity Synbiotics

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
27 Jun 2024
Historique:
received: 12 05 2024
revised: 24 06 2024
accepted: 25 06 2024
medline: 30 6 2024
pubmed: 30 6 2024
entrez: 29 6 2024
Statut: aheadofprint

Résumé

Mulberry (Morus alba L) fruit is traditionally used in Chinese medicine and has several beneficial effects, such as hypoglycemic, hypolipidemic, and anti-oxidative effects. We previously developed the synbiotic mulberry (SM) containing probiotic Lactobacilli, prebiotic inulin, and mulberry powder. In food supplement development, toxicity is the most important criterion in food and drug regulations before commercialization. Thus, this study aimed to investigate the subchronic toxicity of SM in male and female Wistar rats to evaluate its biosafety. The subchronic toxicity study was conducted by daily oral administration of SM at doses of 250, 500, and 1000 mg/kgBW for 90 days. Male and female rats were evaluated for body weight, organ coefficients, biochemical and hematological parameters, and vital organ histology. The results showed no mortality or toxic changes in the subchronic toxicity study. These results suggested that no observed adverse effect level (NOAEL) of SM in male and female rats has been considered at 1000 mg/kgBW for subchronic toxicity study.

Identifiants

DOI: 10.1016/j.fct.2024.114843 PMID: 38944142
pubmed: 38944142
pii: S0278-6915(24)00409-5
doi: 10.1016/j.fct.2024.114843
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

114843

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest None

Auteurs

Atcharaporn Ontawong (A)

Division of Physiology, School of Medical Sciences, University of Phayao, 19 Moo 2 Mae-Ka District, Muang, Phayao, Thailand 56000;. Electronic address: atcharaporn.on@up.ac.th.

Pairote Wongputtisin (P)

Program in Biotechnology, Faculty of Science, Maejo University, Chiang Mai, Thailand 50290;. Electronic address: pairotewong@gmail.com.

Arthid Thim-Uam (A)

Division of Biochemistry, School of Medical Sciences, University of Phayao, 19 Moo 2 Mae-Ka District, Muang, Phayao, Thailand 56000;. Electronic address: arthidth@gmail.com.

Sirinat Pengnet (S)

Division of Physiology, School of Medical Sciences, University of Phayao, 19 Moo 2 Mae-Ka District, Muang, Phayao, Thailand 56000;. Electronic address: sirinat.pe@up.ac.th.

Narongsuk Munkong (N)

Department of Pathology, School of Medicine, University of Phayao, 19 Moo 2 Mae-Ka District, Muang, Phayao, Thailand 56000;. Electronic address: jittmunkong@gmail.com.

Kullanat Kuntakhut (K)

Center of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, 63, Sansai-Phrao Street, Sansai, Chiang Mai, Thailand 50290;. Electronic address: kullanat.ktk@gmail.com.

Prathakphong Riyamongkhol (P)

Laboratory Animal Research Center, University of Phayao, Phayao, Thailand 56000;. Electronic address: lar_bio@hotmail.com.

Dej Mann (D)

Laboratory Animal Research Center, University of Phayao, Phayao, Thailand 56000;. Electronic address: dejmann@hotmail.com.

Doungporn Amornlerdpison (D)

Center of Excellence in Agricultural Innovation for Graduate Entrepreneur, Maejo University, 63, Sansai-Phrao Street, Sansai, Chiang Mai, Thailand 50290;; Faculty of Fisheries Technology and Aquatic Resources, Maejo University, Chiang Mai, Thailand 50290. Electronic address: doungporn_a@mju.ac.th.

Classifications MeSH