MK-0608 inhibits in vitro and in vivo RNA replication of infectious pancreatic necrosis virus.

IPNV MK-0608 RdRp antiviral compound rainbow trout

Journal

Fish & shellfish immunology
ISSN: 1095-9947
Titre abrégé: Fish Shellfish Immunol
Pays: England
ID NLM: 9505220

Informations de publication

Date de publication:
27 Jun 2024
Historique:
received: 10 01 2024
revised: 16 06 2024
accepted: 26 06 2024
medline: 30 6 2024
pubmed: 30 6 2024
entrez: 29 6 2024
Statut: aheadofprint

Résumé

Infectious pancreatic necrosis virus (IPNV) is an important pathogen that is threatening the worldwide salmon and trout industry. But there is no therapeutic drug available for now. In this study, we demonstrate that MK-0608 is highly efficient against IPNV and low cytotoxic, with a 50% effective concentration (EC

Identifiants

DOI: 10.1016/j.fsi.2024.109732 PMID: 38944252
pubmed: 38944252
pii: S1050-4648(24)00377-2
doi: 10.1016/j.fsi.2024.109732
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109732

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest All authors declare that no conflicts of interest exist.

Auteurs

Linfang Li (L)

University of Shanghai Ocean University, College of Fisheries and Life Sciences, Shanghai, China; Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences.

Jingzhuang Zhao (J)

Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China.

Yizhi Shao (Y)

Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China.

Jie Ma (J)

Department of Fish and Wildlife Sciences, University of Idaho, USA.

Tongyan Lu (T)

Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China. Electronic address: lutongyan@hrfri.ac.cn.

Liming Xu (L)

Department of Aquatic Animal Diseases and Control, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences; Key Laboratory of Aquatic Animal Diseases and Immune Technology of Heilongjiang Province, Harbin, China. Electronic address: lmxu0917@163.com.

Classifications MeSH