Etiology of the Neonatal Hypoglycemias.

Humans Infant, Newborn Hypoglycemia / etiology Blood Glucose / analysis Insulin Hyperinsulinism / diagnosis
Beta cell Hyperinsulinism Insulin Ketones Neonate

Journal

Advances in pediatrics
ISSN: 1878-1926
Titre abrégé: Adv Pediatr
Pays: United States
ID NLM: 0370436

Informations de publication

Date de publication:
Aug 2024
Historique:
medline: 30 6 2024
pubmed: 30 6 2024
entrez: 29 6 2024
Statut: ppublish

Résumé

To provide a more appropriate foundation for dealing with the problem of hypoglycemia in newborn infants, this article focuses on the mechanisms which underlie the various forms of neonatal hypoglycemia and discusses their implications for newborn care. Evidence indicates that all of the major forms of neonatal hypoglycemia are the result of hyperinsulinism due to dysregulation of pancreatic islet insulin secretion. Based on these observations, the authors propose that routine measurement of B-hydroxybutyrate should be considered an essential part of glucose monitoring in newborn infants.

Identifiants

DOI: 10.1016/j.yapd.2024.03.001 PMID: 38944478
pubmed: 38944478
pii: S0065-3101(24)00325-6
doi: 10.1016/j.yapd.2024.03.001
pii:
doi:

Substances chimiques

Blood Glucose 0
Insulin 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

119-134

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure C.A. Stanley serves on the Data Safety Monitoring Board for Zealand Pharma clinical trials in hyperinsulinism. D.D. De Leon has received consulting fees from Zealand Pharma A/S, Crinetics Pharmaceuticals, Hanmi Pharmaceuticals, Eiger Pharma, Twist Biosciences, and Rhythm Pharmaceuticals. Diva D. De Leon has received research funding from Zealand Pharma A/S, Rezolute, Crinetics Pharmaceuticals, Hanmi Pharmaceuticals, Twist Biosciences, Eiger Pharma, and Ultragenyx, United States for studies not discussed in this article. D.D. De Leon and C.A. Stanley serve on the Scientific Advisory Board for Congenital Hyperinsulinism International.

Auteurs

Charles A Stanley (CA)

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Diva D De Leon (DD)

Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address: deleon@chop.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Etiology of the Neonatal Hypoglycemias.
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Etiology of the Neonatal Hypoglycemias.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hypoglycémie › Etiology of the Neonatal Hypoglycemias.
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Etiology of the Neonatal Hypoglycemias.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Etiology of the Neonatal Hypoglycemias.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hyperinsulinisme › Etiology of the Neonatal Hypoglycemias.