Management of Pheochromocytomas and Paragangliomas.

Humans Pheochromocytoma / therapy Adrenal Gland Neoplasms / therapy Paraganglioma / therapy Adrenalectomy / methods
Adrenal Catecholamines Neuroendocrine Paraganglioma Pheochromocytoma tumor

Journal

The Surgical clinics of North America
ISSN: 1558-3171
Titre abrégé: Surg Clin North Am
Pays: United States
ID NLM: 0074243

Informations de publication

Date de publication:
Aug 2024
Historique:
medline: 30 6 2024
pubmed: 30 6 2024
entrez: 29 6 2024
Statut: ppublish

Résumé

Pheochromocytomas and paragangliomas are distinctive neuroendocrine tumors which frequently produce excess catecholamines with resultant cardiovascular morbidity. These tumors have a strong genetic component, with up to 40% linked to hereditary pathogenic variants; therefore, germline genetic testing is recommended for all patients. Surgical resection offers the only potential cure in the case of localized disease. Given the potential for catecholaminergic crises, appropriate perioperative management is crucial, and all patients should undergo alpha-adrenergic blockade before resection. Therapeutic options for metastatic disease are limited and include surgical debulking, radiopharmaceutical therapies, and conventional chemotherapy.

Identifiants

DOI: 10.1016/j.suc.2024.02.014 PMID: 38944505
pubmed: 38944505
pii: S0039-6109(24)00030-6
doi: 10.1016/j.suc.2024.02.014
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

863-881

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure H. Wachtel received support from the National Institutes of Health, United States National Cancer Institute, United States Grant #K08 CA270385.

Auteurs

Jesse E Passman (JE)

Department of Surgery, University of Pennsylvania Health System, 3400 Spruce Street, 4th Floor, Maloney Building, Philadelphia, PA 19104, USA. Electronic address: Jesse.passman@pennmedicine.upenn.edu.

Heather Wachtel (H)

Department of Surgery, University of Pennsylvania Health System, 3400 Spruce Street, 4th Floor, Maloney Building, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Management of Pheochromocytomas and Paragangliomas.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Paragangliome › Phéochromocytome › Management of Pheochromocytomas and Paragangliomas.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs de la surrénale › Management of Pheochromocytomas and Paragangliomas.
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Paragangliome › Management of Pheochromocytomas and Paragangliomas.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie des glandes endocrines › Surrénalectomie › Management of Pheochromocytomas and Paragangliomas.