Human intestinal stromal cells promote homeostasis in normal mucosa but inflammation in Crohn's disease in a retinoic acid-deficient manner.

Crohn’s disease Stromal cells mucosa retinaldeyde reductase retinoic acid

Journal

Mucosal immunology
ISSN: 1935-3456
Titre abrégé: Mucosal Immunol
Pays: United States
ID NLM: 101299742

Informations de publication

Date de publication:
28 Jun 2024
Historique:
received: 13 02 2024
revised: 18 06 2024
accepted: 24 06 2024
medline: 1 7 2024
pubmed: 1 7 2024
entrez: 30 6 2024
Statut: aheadofprint

Résumé

Intestinal stromal cells (SCs), which synthesize the extracellular matrix that gives the mucosa its structure, are newly appreciated to play a role in mucosal inflammation. Here we show that human intestinal vimentin

Identifiants

DOI: 10.1016/j.mucimm.2024.06.009 PMID: 38945396
pubmed: 38945396
pii: S1933-0219(24)00063-1
doi: 10.1016/j.mucimm.2024.06.009
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Lesley E Smythies (LE)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294. Electronic address: lsmythies@uabmc.edu.

Olga V Belyaeva (OV)

Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry.

Katie L Alexander (KL)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Diane Bimczok (D)

Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717 University of Alabama at Birmingham, Birmingham, Alabama 35294.

Heidi J Nick (HJ)

Department of Pediatrics, National Jewish Health, Denver, CO 80206.

Carolina A Serrano (CA)

Department of Pediatric Gastroenterology and Nutrition, Faculty of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile.

Kayci R Huff (KR)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Marie Nearing (M)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Lois Musgrove (L)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Emily H Poovey (EH)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Jaleesa Garth (J)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Kirk Russ (K)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Kondal R K K Baig (K)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

David K Crossman (DK)

Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.

Shajan Peter (S)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Jamie A Cannon (JA)

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294.

Charles O Elson (CO)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.

Natalia Y Kedishvili (NY)

Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry.

Phillip D Smith (PD)

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294. Electronic address: pdsmith@uabmc.edu.

Classifications MeSH