Modulation of bitter taste receptors by yeast extracts.
Bitter receptor
Bitterness
Inhibition
Masking
TAS2R
Yeast extract
Journal
Food research international (Ottawa, Ont.)
ISSN: 1873-7145
Titre abrégé: Food Res Int
Pays: Canada
ID NLM: 9210143
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
27
03
2024
revised:
21
05
2024
accepted:
01
06
2024
medline:
1
7
2024
pubmed:
1
7
2024
entrez:
30
6
2024
Statut:
ppublish
Résumé
Yeast extracts (YEs) are used in foods because of their flavour properties and ability to reduce bitterness. The adenosine 5'-monophosphate (AMP) found in YEs is known to decrease the bitterness of some compounds. This study aimed to investigate the ability of YEs to inhibit bitter taste receptors (TAS2Rs) using in vitro cell-based assays. A screen of TAS2Rs activated by AMP and YEs revealed that AMP and the AMP-rich YE activated more TAS2Rs. The inhibitory effect of the AMP-rich YE on seven TAS2Rs activated by bitter agonists was studied. YE reduced TAS2R activation, increased the EC
Identifiants
pubmed: 38945612
pii: S0963-9969(24)00666-5
doi: 10.1016/j.foodres.2024.114596
pii:
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
taste receptors, type 2
0
Adenosine Monophosphate
415SHH325A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114596Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: BRIAND reports financial support was provided by Biospringer by Lesaffre. THOMAS and MENIN are employees of Biospringer by Lessafre which manufactures and supplies YEs. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.