Adipose stem cells drive T cell infiltration in obesity.
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
29 Jun 2024
29 Jun 2024
Historique:
received:
12
06
2024
revised:
19
06
2024
accepted:
20
06
2024
medline:
1
7
2024
pubmed:
1
7
2024
entrez:
30
6
2024
Statut:
aheadofprint
Résumé
Obesity is often associated with adipose tissue (AT) inflammation and immune cell infiltration. Writing recently in Cell Reports, Liao et al. investigated the mechanisms of T cell infiltration of AT using single cell (sc)RNA-sequencing (RNA-seq), transplantation studies, in vitro co-cultures, and knock-out mice. They highlighted the crucial role of C-C motif chemokine ligand 5 (CCL5)-secreting adipose stem cells (ASCs), offering insights for potential therapies.
Identifiants
pubmed: 38945796
pii: S1043-2760(24)00174-7
doi: 10.1016/j.tem.2024.06.013
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.