Branched-Chain Amino Acids Deficiency Promotes Diabetic Neuropathic Pain Through Upregulating LAT1 and Inhibiting Kv1.2 Channel.
Kv1.2
L‐type amino acid transporter 1
branched‐chain amino acids
diabetic neuropathic pain
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
revised:
18
06
2024
received:
27
02
2024
medline:
1
7
2024
pubmed:
1
7
2024
entrez:
1
7
2024
Statut:
aheadofprint
Résumé
Diabetic neuropathic pain (DNP), one of the most common complications of diabetes, is characterized by bilateral symmetrical distal limb pain and substantial morbidity. To compare the differences is aimed at serum metabolite levels between 81 DNP and 73 T2DM patients without neuropathy and found that the levels of branched-chain amino acids (BCAA) are significantly lower in DNP patients than in T2DM patients. In high-fat diet/low-dose streptozotocin (HFD/STZ)-induced T2DM and leptin receptor-deficient diabetic (db/db) mouse models, it is verified that BCAA deficiency aggravated, whereas BCAA supplementation alleviated DNP symptoms. Mechanistically, using a combination of RNA sequencing of mouse dorsal root ganglion (DRG) tissues and label-free quantitative proteomic analysis of cultured cells, it is found that BCAA deficiency activated the expression of L-type amino acid transporter 1 (LAT1) through ATF4, which is reversed by BCAA supplementation. Abnormally upregulated LAT1 reduced Kv1.2 localization to the cell membrane, and inhibited Kv1.2 channels, thereby increasing neuronal excitability and causing neuropathy. Furthermore, intraperitoneal injection of the LAT1 inhibitor, BCH, alleviated DNP symptoms in mice, confirming that BCAA-deficiency-induced LAT1 activation contributes to the onset of DNP. These findings provide fresh insights into the metabolic differences between DNP and T2DM, and the development of approaches for the management of DNP.
Identifiants
pubmed: 38946582
doi: 10.1002/advs.202402086
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2402086Subventions
Organisme : Key Development Programs of Basic Research of China
ID : Nos. 2020YFA0803601
Organisme : Key Development Programs of Basic Research of China
ID : 2019YFA0801900
Organisme : National Natural Science Foundation of China
ID : 82330048
Organisme : National Natural Science Foundation of China
ID : 82170236
Organisme : National Natural Science Foundation of China
ID : 81700212
Organisme : National Natural Science Foundation of China
ID : 32370824
Organisme : National Natural Science Foundation of China
ID : 32000895
Organisme : National Natural Science Foundation of China
ID : 82300428
Organisme : Program of Shanghai Academic Research Leader
ID : 21XD1421700
Organisme : Innovation Program of the Shanghai Municipal Education Commission
ID : 2023ZKZD24
Organisme : Shanghai Sailing Program
ID : 23YF1425500
Organisme : Innovative research team of high-level local universities in Shanghai
ID : SHSMU-ZDCX20211100
Informations de copyright
© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
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