Malondialdehyde and Zinc May Relate to Severity of Microvascular Complications in Diabetes: A Preliminary Study on Older Adults with Type 2 Diabetes Mellitus in Northeast China.
Humans
Diabetes Mellitus, Type 2
/ blood
Male
Female
Aged
Zinc
/ blood
China
Oxidative Stress
Malondialdehyde
/ blood
Superoxide Dismutase
/ blood
Middle Aged
Blood Glucose
/ analysis
Risk Factors
Diabetic Angiopathies
/ blood
Glycated Hemoglobin
/ analysis
Nitric Oxide
/ blood
Antioxidants
Magnesium
/ blood
Lipids
/ blood
Trace Elements
/ blood
Severity of Illness Index
diabetic microvascular complications
older adults
oxidative stress
trace elements
type 2 diabetes mellitus
Journal
Clinical interventions in aging
ISSN: 1178-1998
Titre abrégé: Clin Interv Aging
Pays: New Zealand
ID NLM: 101273480
Informations de publication
Date de publication:
2024
2024
Historique:
received:
18
02
2024
accepted:
07
06
2024
medline:
1
7
2024
pubmed:
1
7
2024
entrez:
1
7
2024
Statut:
epublish
Résumé
Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults. The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated. There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups ( Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.
Sections du résumé
Background
UNASSIGNED
Serum trace elements and oxidative stress factors are related to diabetic microvascular complications. The study was to investigate the complex relationship between trace elements, oxidative stress factors, and the severity of microvascular complications of diabetes in older adults.
Methods
UNASSIGNED
The present study included patients with or without type 2 diabetes, and blood glucose, blood lipids, trace elements (iron, magnesium, zinc), oxidative stress factors (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC)) were evaluated. Risk factors for the severity of diabetic microvascular complications in older adults with diabetes were also estimated.
Results
UNASSIGNED
There were statistically significant differences in fasting blood glucose (FBG), triglycerides (TG), low density lipoprotein (LDL), glycated hemoglobin (HbAlc), MDA, NO, SOD, T-AOC, magnesium, and zinc between the two groups (
Conclusion
UNASSIGNED
Serum trace elements are related to oxidative stress levels in older adults with type 2 diabetes. The more stable trace element in older adults with diabetes, the lower the oxidative stress and the fewer microvascular complications of diabetes.
Identifiants
pubmed: 38948168
doi: 10.2147/CIA.S464615
pii: 464615
pmc: PMC11214795
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Malondialdehyde
4Y8F71G49Q
Superoxide Dismutase
EC 1.15.1.1
Blood Glucose
0
Glycated Hemoglobin
0
Nitric Oxide
31C4KY9ESH
Antioxidants
0
Magnesium
I38ZP9992A
Lipids
0
Trace Elements
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1141-1151Informations de copyright
© 2024 Sun et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests in this work.