1,3,5-Triaza-7-phosphaadamantane and Cyclohexyl Groups Impart to Di-Iron(I) Complex Aqueous Solubility and Stability, and Prominent Anticancer Activity in Cellular and Animal Models.


Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
01 Jul 2024
Historique:
medline: 2 7 2024
pubmed: 2 7 2024
entrez: 1 7 2024
Statut: aheadofprint

Résumé

Using a multigram-scalable synthesis, we obtained nine dinuclear complexes based on nonendogenous iron(I) centers and featuring variable aminocarbyne and P-ligands. One compound from the series (

Identifiants

pubmed: 38951717
doi: 10.1021/acs.jmedchem.4c00641
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Michele De Franco (M)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, I-35131 Padova, Italy.

Lorenzo Biancalana (L)

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, I-56124 Pisa, Italy.

Chiara Zappelli (C)

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, I-56124 Pisa, Italy.

Stefano Zacchini (S)

Department of Industrial Chemistry "Toso Montanari", University of Bologna, Via P. Gobetti 85, I-40129 Bologna, Italy.

Valentina Gandin (V)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, I-35131 Padova, Italy.

Fabio Marchetti (F)

Department of Chemistry and Industrial Chemistry, University of Pisa, Via G. Moruzzi 13, I-56124 Pisa, Italy.

Classifications MeSH