Biomedical Device Surface Treatment by Laser-Driven Hydroxyapatite Penetration-Synthesis Technique for Gapless PEEK-to-Bone Integration.

direct bone integration hydroxyapatite nanosecond laser polyetheretherketone surface treatment

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
21 Jun 2024
Historique:
revised: 19 06 2024
received: 05 04 2024
medline: 2 7 2024
pubmed: 2 7 2024
entrez: 2 7 2024
Statut: aheadofprint

Résumé

Polyetheretherketone (PEEK), a bioinert polymer known for its mechanical properties similar to bone, is capable of averting stress shielding. Due to these attributes, it finds applications in diverse fields like orthopedics, encompassing cervical disc replacement for the neck and spine, along with dentistry and plastic surgery. However, due to insufficient bonding with bone, various methods such as hydroxyapatite (HA) coating on the surface are attempted. Nonetheless, the interface between the polymer and ceramic, two different materials, tended to delaminate after transplantation, posing challenges in preventing implant escape or dislodgement. This research delves into the laser-driven hydroxyapatite penetration-synthesis technique. Differing from conventional coating methods that bond layers of dissimilar materials like HA and PEEK, this technology focuses on synthesizing and infiltrating ionized HA within the PEEK substrate resulting in an interface-free HA-PEEK surface. Conversely, HA-PEEK with this technology applied achieves complete, gap-free direct bone-implant integration.  Our research involved the analysis of various aspects. By means of these, we quantitatively assesed the enhanced bone bonding characteristics of HA-PEEK surfaces treated with this approach and offered and explanation for the mechanism responsible for direct bone integration.

Identifiants

pubmed: 38953344
doi: 10.1002/adhm.202401260
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2401260

Subventions

Organisme : Ministry of Education
ID : RS-2023-00237974
Organisme : KU-KIST Graduate School of Converging Science and Technology
Organisme : Korea Institute of Science and Technology
ID : 2V09840-23-P023
Organisme : Ministry of Science and ICT, South Korea
ID : 9991007189

Informations de copyright

© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.

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Auteurs

Seung-Hoon Um (SH)

Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Regenerative Medicine, Laval University, Quebec City, QC, G1V 0A6, Canada.

Jaehong Lee (J)

Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Minseong Chae (M)

Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 05505, Republic of Korea.

Carlo Paternoster (C)

Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Regenerative Medicine, Laval University, Quebec City, QC, G1V 0A6, Canada.

Francesco Copes (F)

Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Regenerative Medicine, Laval University, Quebec City, QC, G1V 0A6, Canada.

Pascale Chevallier (P)

Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Regenerative Medicine, Laval University, Quebec City, QC, G1V 0A6, Canada.

Dong-Ho Lee (DH)

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea.

Suk-Won Hwang (SW)

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.

Yu-Chan Kim (YC)

Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Hyung-Seop Han (HS)

Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.

Kang-Sik Lee (KS)

Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, 05505, Republic of Korea.

Diego Mantovani (D)

Lab Biomaterials and Bioengineering, CRC-I, Department of Mining, Metallurgical and Materials Engineering and CHU de Quebec Research Centre, Regenerative Medicine, Laval University, Quebec City, QC, G1V 0A6, Canada.

Hojeong Jeon (H)

Biomaterials Research Center, Biomedical Research Division, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea.
KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.

Classifications MeSH