T Helper Cells Producing Granulocyte-Macrophage Colony Stimulating Factor as a Risk Marker for Coronary Heart Disease.

Th17 ThGM coronary heart disease cytokines inflammatory diseases

Journal

Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557

Informations de publication

Date de publication:
02 Jul 2024
Historique:
received: 12 12 2022
medline: 2 7 2024
pubmed: 2 7 2024
entrez: 2 7 2024
Statut: aheadofprint

Résumé

Coronary heart disease (CHD) is related to aberrant aggregation of immune cells in the plaques. This study focused on identification of abnormal T cell subtypes and inflammatory factors in CHD patients. To this end, the subtypes of T cells in peripheral blood of CHD patients (n=141) and healthy controls (n=46) were analyzed by flow cytometry. Plasma concentrations of cytokines were analyzed by multiplex assay. It was shown that the number of T helper cells producing granulocyte-macrophage CSF (GM-CSF) was higher in CHD patients in comparison with healthy controls. In addition, the fractions of Th1 and Th17 cells as well as the levels of IL-4, IL-5, IL-6, and IL-10 in CHD patients also surpassed the control values (p<0.05). However, the level of GM-CSF was insignificantly lower in CHD patients. Thus, we revealed a relationship between the number of T cells producing GM-CSF and the severity of CHD. Our results can be used to develop new potential biomarkers for CHD detection.

Identifiants

DOI: 10.1007/s10517-024-06122-y PMID: 38954298
pubmed: 38954298
doi: 10.1007/s10517-024-06122-y
pii: 10.1007/s10517-024-06122-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

D Mou (D)

Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.

S Wu (S)

Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.

L Jiao (L)

Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.

Y Zhou (Y)

Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China.

X Bai (X)

Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China. baixiufeng@wchscu.cn.
Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China. baixiufeng@wchscu.cn.
National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. baixiufeng@wchscu.cn.

Classifications MeSH