Facile synthesis of elastin nanogels encapsulated decursin for castrated resistance prostate cancer therapy.
Decursin
Drug release
Elastin
Nanogel
Prostate cancer therapy
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 07 2024
02 07 2024
Historique:
received:
15
02
2024
accepted:
26
06
2024
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
2
7
2024
Statut:
epublish
Résumé
Nanogels offer hope for precise drug delivery, while addressing drug delivery hurdles is vital for effective prostate cancer (PCa) management. We developed an injectable elastin nanogels (ENG) for efficient drug delivery system to overcome castration-resistant prostate cancer (CRPC) by delivering Decursin, a small molecule inhibitor that blocks Wnt/βcatenin pathways for PCa. The ENG exhibited favourable characteristics such as biocompatibility, flexibility, and low toxicity. In this study, size, shape, surface charge, chemical composition, thermal stability, and other properties of ENG were used to confirm the successful synthesis and incorporation of Decursin (DEC) into elastin nanogels (ENG) for prostate cancer therapy. In vitro studies demonstrated sustained release of DEC from the ENG over 120 h, with a pH-dependent release pattern. DU145 cell line induces moderate cytotoxicity of DEC-ENG indicates that nanomedicine has an impact on cell viability and helps strike a balance between therapeutics efficacy and safety while the EPR effect enables targeted drug delivery to prostate tumor sites compared to free DEC. Morphological analysis further supported the effectiveness of DEC-ENG in inducing cell death. Overall, these findings highlight the promising role of ENG-encapsulated decursin as a targeted drug delivery system for CRPC.
Identifiants
pubmed: 38956125
doi: 10.1038/s41598-024-65999-x
pii: 10.1038/s41598-024-65999-x
doi:
Substances chimiques
Elastin
9007-58-3
decursin
E95RTO3YQR
Nanogels
0
Antineoplastic Agents
0
Benzopyrans
0
Butyrates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
15095Subventions
Organisme : Department of Science and Technology (DST), SERB
ID : CRG/2021/001369
Organisme : National Research Foundation of Korea by the Ministry of Education, Science, and Technology
ID : 2018R1D1A1B06051438
Informations de copyright
© 2024. The Author(s).
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