Neuroglia in cognitive reserve.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
02 Jul 2024
Historique:
received: 09 03 2024
accepted: 21 06 2024
revised: 18 06 2024
medline: 3 7 2024
pubmed: 3 7 2024
entrez: 2 7 2024
Statut: aheadofprint

Résumé

The concept of cognitive reserve was born to account for the disjunction between the objective extent of brain damage in pathology and its clinical and intellectual outcome. The cognitive reserve comprises structural (brain reserve) and functional (brain maintenance, resilience, compensation) aspects of the nervous tissue reflecting exposome-driven life-long plasticity, which defines the ability of the brain to withstand aging and pathology. The mechanistic background of this concept was primarily focused on adaptive changes in neurones and neuronal networks. We present arguments favoring the more inclusive view, positing that neuroglia are fundamental for defining the cognitive reserve through homeostatic, neuroprotective, and neurodegenerative mechanisms. Neuroglia are critical for the life-long shaping of synaptically connected neuronal circuits as well as the brain connectome thus defining cognitive reserve. Neuroglial homeostatic and protective physiological responses define brain maintenance and resilience, while neuroglia regenerative capabilities are critical for brain compensation in pathology. Targeting neuroglia may represent an untrodden path for prolonging cognitive longevity.

Identifiants

pubmed: 38956370
doi: 10.1038/s41380-024-02644-z
pii: 10.1038/s41380-024-02644-z
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Alexei Verkhratsky (A)

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, M13 9PT, UK. Alexej.Verkhratsky@manchester.ac.uk.
Department of Neurosciences, University of the Basque Country, 48940, Leioa, Bizkaia, Spain. Alexej.Verkhratsky@manchester.ac.uk.
IKERBASQUE Basque Foundation for Science, Bilbao, Spain. Alexej.Verkhratsky@manchester.ac.uk.
University of Ljubljana, Institute of Pathophysiology, Laboratory of Neuroendocrinology and Molecular Cell Physiology, Zaloška cesta 4, SI-1000, Ljubljana, Slovenia. Alexej.Verkhratsky@manchester.ac.uk.
Celica, BIOMEDICAL, Technology Park 24, 1000, Ljubljana, Slovenia. Alexej.Verkhratsky@manchester.ac.uk.

Robert Zorec (R)

University of Ljubljana, Institute of Pathophysiology, Laboratory of Neuroendocrinology and Molecular Cell Physiology, Zaloška cesta 4, SI-1000, Ljubljana, Slovenia. robert.zorec@mf.uni-lj.si.
Celica, BIOMEDICAL, Technology Park 24, 1000, Ljubljana, Slovenia. robert.zorec@mf.uni-lj.si.

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