Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair.
Fanconi anemia
PCNA monoubiquitination
interstrand crosslink
mismatch repair
replication stress
Journal
PNAS nexus
ISSN: 2752-6542
Titre abrégé: PNAS Nexus
Pays: England
ID NLM: 9918367777906676
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
received:
19
07
2023
accepted:
03
06
2024
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
3
7
2024
Statut:
epublish
Résumé
The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is facilitated by REV1 or site-specific monoubiquitination of proliferating cell nuclear antigen (PCNA) (PCNA-Ub) at lysine 164 (K164). A
Identifiants
pubmed: 38957451
doi: 10.1093/pnasnexus/pgae242
pii: pgae242
pmc: PMC11217772
doi:
Types de publication
Journal Article
Langues
eng
Pagination
pgae242Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.