Neurovascular coupling, functional connectivity, and cerebrovascular endothelial extracellular vesicles as biomarkers of mild cognitive impairment.
endothelium
extracellular vesicles
functional connectivity
mild cognitive impairment
neurovascular coupling
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
03 Jul 2024
03 Jul 2024
Historique:
revised:
16
05
2024
received:
16
02
2024
accepted:
22
05
2024
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
3
7
2024
Statut:
aheadofprint
Résumé
Mild cognitive impairment (MCI) is a prodromal stage of dementia. Understanding the mechanistic changes from healthy aging to MCI is critical for comprehending disease progression and enabling preventative intervention. Patients with MCI and age-matched controls (CN) were administered cognitive tasks during functional near-infrared spectroscopy (fNIRS) recording, and changes in plasma levels of extracellular vesicles (EVs) were assessed using small-particle flow cytometry. Neurovascular coupling (NVC) and functional connectivity (FC) were decreased in MCI compared to CN, prominently in the left-dorsolateral prefrontal cortex (LDLPFC). We observed an increased ratio of cerebrovascular endothelial EVs (CEEVs) to total endothelial EVs in patients with MCI compared to CN, correlating with structural MRI small vessel ischemic damage in MCI. LDLPFC NVC, CEEV ratio, and LDLPFC FC had the highest feature importance in the random Forest group classification. NVC, CEEVs, and FC predict MCI diagnosis, indicating their potential as markers for MCI cerebrovascular pathology. Neurovascular coupling (NVC) is impaired in mild cognitive impairment (MCI). Functional connectivity (FC) compensation mechanism is lost in MCI. Cerebrovascular endothelial extracellular vesicles (CEEVs) are increased in MCI. CEEV load strongly associates with cerebral small vessel ischemic lesions in MCI. NVC, CEEVs, and FC predict MCI diagnosis over demographic and comorbidity factors.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The American Heart Association
ID : AHA941290
Organisme : The American Heart Association
ID : AHA932980
Organisme : The American Heart Association
ID : 966924
Organisme : The American Heart Association
ID : 23DIVSUP1070991
Organisme : NIA NIH HHS
ID : RF1AG072295
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG055395
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG068295
Pays : United States
Organisme : NIA NIH HHS
ID : K01AG073614
Pays : United States
Organisme : NIA NIH HHS
ID : K01AG073613
Pays : United States
Organisme : NIA NIH HHS
ID : R03AG070479
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG075834
Pays : United States
Organisme : NIA NIH HHS
ID : R21AG080775
Pays : United States
Organisme : Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID : R01HD109157
Organisme : NINDS NIH HHS
ID : R01NS100782
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1NS085002
Pays : United States
Organisme : U.S. Department of Veterans Affairs
ID : CX002578
Organisme : U.S. Department of Veterans Affairs
ID : CX000340
Organisme : NCI NIH HHS
ID : R01CA255840
Pays : United States
Organisme : Oklahoma Shared Clinical and Translational Resources (OSCTR)
Organisme : NIGMS NIH HHS
ID : U54GM104938
Pays : United States
Organisme : NIA-funded Geroscience Training Program in Oklahoma
ID : T32AG052363
Informations de copyright
© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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