A nanofluidic spiking synapse.

Action Potentials / physiology Synapses / physiology Polystyrenes / chemistry Nanotechnology / methods
bionic synapse chemical tunability nanofluidic potential spiking transmembrane

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
09 Jul 2024
Historique:
medline: 3 7 2024
pubmed: 3 7 2024
entrez: 3 7 2024
Statut: ppublish

Résumé

Currently, the nanofluidic synapse can only perform basic neuromorphic pulse patterns. One immediate problem that needs to be addressed to further its capability of brain-like computing is the realization of a nanofluidic spiking device. Here, we report the use of a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate membrane to achieve bionic ionic current-induced spiking. In addition to the simulation of various electrical pulse patterns, our synapse could produce transmembrane ionic current-induced spiking, which is highly analogous to biological action potentials with similar phases and excitability. Moreover, the spiking properties could be modulated by ions and neurochemicals. We expect that this work could contribute to biomimetic spiking computing in solution.

Identifiants

DOI: 10.1073/pnas.2403143121 PMID: 38959041
pubmed: 38959041
doi: 10.1073/pnas.2403143121
doi:

Substances chimiques

Polystyrenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2403143121

Subventions

Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 22034003
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 22174063 22374066
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 21327902

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Yi-Tong Xu (YT)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
ORCID: 0000-0002-4613-9345

Si-Yuan Yu (SY)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Zheng Li (Z)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Bo-Han Kou (BH)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Jian-Xiang Pang (JX)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Wei-Wei Zhao (WW)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
ORCID: 0000-0002-8179-4775

Hong-Yuan Chen (HY)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Jing-Juan Xu (JJ)

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
ORCID: 0000-0001-9579-9318

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Potentiels de membrane › Potentiels d'action › A nanofluidic spiking synapse.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › A nanofluidic spiking synapse.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polystyrènes › A nanofluidic spiking synapse.
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Nanotechnologie › A nanofluidic spiking synapse.