Management of Extracorporeal Membrane Oxygenation Anticoagulation in the Perioperative Period: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.
Journal
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
ISSN: 1529-7535
Titre abrégé: Pediatr Crit Care Med
Pays: United States
ID NLM: 100954653
Informations de publication
Date de publication:
01 Jul 2024
01 Jul 2024
Historique:
medline:
3
7
2024
pubmed:
3
7
2024
entrez:
3
7
2024
Statut:
ppublish
Résumé
To derive systematic review-informed, modified Delphi consensus regarding the management of children on extracorporeal membrane oxygenation (ECMO) undergoing invasive procedures or interventions developed by the Pediatric Anticoagulation on ECMO CollaborativE (PEACE) Consensus Conference. A structured literature search was performed using PubMed, EMBASE, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021. ECMO anticoagulation and hemostasis management in the perioperative period and during procedures. Two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts. Seventeen references were used for data extraction and informed recommendations. Evidence tables were constructed using a standardized data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. The evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation system. Forty-eight experts met over 2 years to develop evidence-based recommendations and, when evidence was lacking, expert-based consensus statements for the management of bleeding and thrombotic complications in pediatric ECMO patients. A web-based modified Delphi process was used to build consensus via the Research And Development/University of California Appropriateness Method. Consensus was defined as greater than 80% agreement. Four good practice statements, 7 recommendations, and 18 consensus statements are presented. Although agreement among experts was strong, important future research is required in this population for evidence-informed recommendations.
Identifiants
pubmed: 38959360
doi: 10.1097/PCC.0000000000003490
pii: 00130478-202407001-00007
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Consensus Development Conference
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e53-e65Investigateurs
Peta M A Alexander
(PMA)
Melania M Bembea
(MM)
Katherine Cashen
(K)
Ira M Cheifetz
(IM)
Heidi Dalton
(H)
Adam S Himebauch
(AS)
Oliver Karam
(O)
Katie M Moynihan
(KM)
Fracp Fcic
(F)
Marianne E Nellis
(ME)
Caroline Ozment
(C)
Lakshmi Raman
(L)
Natalie E Rintoul
(NE)
Ahmed S Said
(AS)
Arun Saini
(A)
Marie E Steiner
(ME)
Ravi R Thiagarajan
(RR)
Kevin Watt
(K)
Ariane Willems
(A)
Nicole D Zantek
(ND)
Ryan P Barbaro
(RP)
Katherine Steffen
(K)
Adam M Vogel
(AM)
Christopher Almond
(C)
Marc M Anders
(MM)
Gail M Annich
(GM)
Leonardo R Brandão
(LR)
Wayne Chandler
(W)
Megan Delaney
(M)
Robert DiGeronimo
(R)
Sitaram Emani
(S)
Samir K L Gadepalli
(SKL)
Alejandro V Garcia
(AV)
Bereketeab Haileselassie
(B)
Adam S Himebauch
(AS)
Robert Hyslop
(R)
Martin C J Kneyber
(MCJ)
Lisa Baumann Kreuziger
(L)
Jennifer Le
(J)
Laura Loftis
(L)
Ali B V McMichael
(ABV)
D Michael McMullan
(D)
Paul Monagle
(P)
Kathleen Nicol
(K)
Matthew L Paden
(ML)
Jason Patregnani
(J)
John R Priest
(JR)
Leslie Raffini
(L)
Lindsay M Ryerson
(LM)
Steven R Sloan
(SR)
Jun Teruya
(J)
Andrew R Yates
(AR)
Alison Gehred
(A)
Elizabeth Lyman
(E)
Jennifer A Muszynski
(JA)
Informations de copyright
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
Déclaration de conflit d'intérêts
The Executive Committee (Drs. Alexander, Muszynski, Bembea, Cheifetz, Steiner, and Barbaro) served as arbitrators for conflict of interest management. Dr. Alexander’s institution received funding from Novartis (Prospective Trial to Assess the Angiotensin ReceptorBlocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Inhibitor for the Medical Treatment of Pediatric HF [PANORAMA-HF]). Drs. Muszynski and Alexander’s institutions received funding from the National Institutes of Health (NIH); they received support for article research from the NIH. Dr. Alexander’s institution received funding from the Extracorporeal Life Support Organization and Novartis. Dr. Emani received funding from Cheisi Pharma and Cellvie Bio. The remaining authors have disclosed that they do not have any potential conflicts of interest.
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