Evaluation of bone density and microarchitecture in adult patients with X-linked hypophosphatemic rickets: A pilot longitudinal study.

DXA HRpQCT X-linked Hypophosphatemia

Journal

Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048

Informations de publication

Date de publication:
01 Jul 2024
Historique:
received: 08 03 2024
revised: 24 06 2024
accepted: 26 06 2024
medline: 4 7 2024
pubmed: 4 7 2024
entrez: 3 7 2024
Statut: aheadofprint

Résumé

X-linked Hypophosphatemia (XLH) is the most common type of inherited rickets. Although the clinical features are well characterized, bone structure, mineralization, and biomechanical properties are poorly known. Our aim was to analyze bone properties in the appendicular and axial skeleton of adults with XLH. In this observational case-control study, each affected patient (N = 14; 9 females; age 50 ± 15 years) was matched by sex, age and body mass index to a minimum of two healthy controls (N = 34). Dual-energy X-ray Absorptiometry (DXA) analyses revealed that areal bone mineral density (aBMD) was higher in XLH patients at the lumbar spine (Z score mean difference = +2.47 SD, P value = 1.4 × 10

Identifiants

DOI: 10.1016/j.bone.2024.117179 PMID: 38960298
pubmed: 38960298
pii: S8756-3282(24)00168-6
doi: 10.1016/j.bone.2024.117179
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

117179

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest TFB and MCS disclose their participation in a sponsored symposium by Kyowa Kirin. MCS received a research grant by Kyowa Kirin.

Auteurs

Thomas Funck-Brentano (T)

BIOSCAR UMRS 1132, INSERM, Université Paris Cité, F-75475 Paris, France; Assistance Publique des Hôpitaux de Paris, Lariboisière Hospital, DMU Locomotion, Department of Rheumatology, F-75475 Paris, France; National Reference Center For Rare Bone Diseases, Lariboisière Hospital, APHP.Nord, Filière OSCAR, F-75475 Paris, France. Electronic address: thomas.funck-brentano@aphp.fr.

Arnaud Vanjak (A)

BIOSCAR UMRS 1132, INSERM, Université Paris Cité, F-75475 Paris, France; Assistance Publique des Hôpitaux de Paris, Lariboisière Hospital, DMU Locomotion, Department of Rheumatology, F-75475 Paris, France; National Reference Center For Rare Bone Diseases, Lariboisière Hospital, APHP.Nord, Filière OSCAR, F-75475 Paris, France.

Agnes Ostertag (A)

BIOSCAR UMRS 1132, INSERM, Université Paris Cité, F-75475 Paris, France.

Maria Nethander (M)

Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Sweden.

Sylvie Fernandez (S)

Assistance Publique des Hôpitaux de Paris, Lariboisière Hospital, DMU Locomotion, Department of Rheumatology, F-75475 Paris, France.

Corinne Collet (C)

Imagine Institut, Necker Hospital, Université Paris Cité, F-75475 Paris, France.

Didier Hans (D)

Center of Bone Diseases, Bone & Joint Department, Lausanne University Hospital, Lausanne, Switzerland.

Bert van Rietbergen (B)

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.

Martine Cohen-Solal (M)

BIOSCAR UMRS 1132, INSERM, Université Paris Cité, F-75475 Paris, France; Assistance Publique des Hôpitaux de Paris, Lariboisière Hospital, DMU Locomotion, Department of Rheumatology, F-75475 Paris, France; National Reference Center For Rare Bone Diseases, Lariboisière Hospital, APHP.Nord, Filière OSCAR, F-75475 Paris, France.

Classifications MeSH