The Role of Fibroblast Activation Protein in Glioblastoma and Gliosarcoma: A Comparison of Tissue,

68Ga-FAPI-46 PET FAP glioblastoma gliosarcoma theranostic

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
03 Jul 2024
Historique:
received: 02 12 2023
accepted: 22 05 2024
medline: 4 7 2024
pubmed: 4 7 2024
entrez: 3 7 2024
Statut: aheadofprint

Résumé

Despite their unique histologic features, gliosarcomas belong to the group of glioblastomas and are treated according to the same standards. Fibroblast activation protein (FAP) is a component of a tumor-specific subpopulation of fibroblasts that plays a critical role in tumor growth and invasion. Some case studies suggest an elevated expression of FAP in glioblastoma and a particularly strong expression in gliosarcoma attributed to traits of predominant mesenchymal differentiation. However, the prognostic impact of FAP and its diagnostic and therapeutic potential remain unclear. Here, we investigate the clinical relevance of FAP expression in gliosarcoma and glioblastoma and how it correlates with

Identifiants

DOI: 10.2967/jnumed.123.267151 PMID: 38960714
pubmed: 38960714
pii: jnumed.123.267151
doi: 10.2967/jnumed.123.267151
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Christoph Oster (C)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.
German Cancer Consortium (DKTK), Partner Site Essen-Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ-Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Lukas Kessler (L)

Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany.

Tobias Blau (T)

Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Kathy Keyvani (K)

Institute of Neuropathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Kim M Pabst (KM)

Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany.

Wolfgang P Fendler (WP)

Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany.

Pedro Fragoso Costa (P)

Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany.

Lazaros Lazaridis (L)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Teresa Schmidt (T)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Jonas Feldheim (J)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Daniela Pierscianek (D)

Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.
Department of Neurosurgery and Spine Surgery, St. Marienhospital Lünen, Lünen, Germany.

Hans Ulrich Schildhaus (HU)

Institute of Pathology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.
Discovery Life Sciences Biomarker Services GmbH, Kassel, Germany.

Ulrich Sure (U)

Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Yahya Ahmadipour (Y)

Department of Neurosurgery and Spine Surgery, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Christoph Kleinschnitz (C)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Nika Guberina (N)

Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Martin Stuschke (M)

Department of Radiotherapy, University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Cornelius Deuschl (C)

Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.

Björn Scheffler (B)

German Cancer Consortium (DKTK), Partner Site Essen-Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ-Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany; and.

Ken Herrmann (K)

Department of Nuclear Medicine, University of Duisburg-Essen, and German Cancer Consortium (DKTK)-University Hospital Essen, Essen, Germany; and National Center for Tumor Diseases (NCT), NCT West, Essen, Germany.
National Center for Tumor Diseases (NCT), NCT West, Heidelberg, Germany.

Sied Kebir (S)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany.
German Cancer Consortium (DKTK), Partner Site Essen-Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ-Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Martin Glas (M)

Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neurooncology, University Medicine Essen, University Duisburg-Essen, Essen, Germany; martin.glas@uk-essen.de.
German Cancer Consortium (DKTK), Partner Site Essen-Düsseldorf, Partnership Between DKFZ and University Hospital Essen, Essen, Germany; and DKFZ-Division of Translational Neurooncology at West German Cancer Center (WTZ), University Medicine Essen, University Duisburg-Essen, Essen, Germany.

Classifications MeSH