Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
03 Jul 2024
Historique:
received: 09 06 2023
accepted: 20 06 2024
medline: 4 7 2024
pubmed: 4 7 2024
entrez: 3 7 2024
Statut: epublish

Résumé

Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the gastrointestinal tract to tolerate exposure to food and commensal microbiome without triggering inflammatory responses. Repeating exposure to type II collagen induces oral tolerance and inhibits induction of arthritis, a chronic inflammatory joint condition. Although some mechanisms underlying oral tolerance are described, how dysregulation of gut immune networks impacts on inflammation of distant tissues like the joints is unclear. We used undenatured type II collagen in a prophylactic regime -7.33 mg/kg three times/week- to describe the mechanisms associated with protective oral immune-therapy (OIT) in gut and joint during experimental Collagen-Induced Arthritis (CIA). OIT reduced disease incidence to 50%, with reduced expression of IL-17 and IL-22 in the joints of asymptomatic mice. Moreover, whilst the gut tissue of arthritic mice shows substantial damage and activation of tissue-specific immune networks, oral administration of undenatured type II collagen protects against gut pathology in all mice, symptomatic and asymptomatic, rewiring IL-17/IL-22 networks. Furthermore, gut fucosylation and microbiome composition were also modulated. These results corroborate the relevance of the gut-joint axis in arthritis, showing novel regulatory mechanisms linked to therapeutic OIT in joint disease.

Identifiants

pubmed: 38961129
doi: 10.1038/s42003-024-06476-z
pii: 10.1038/s42003-024-06476-z
doi:

Substances chimiques

Collagen Type II 0
Interleukin-17 0
Interleukin-22 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

804

Informations de copyright

© 2024. The Author(s).

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Auteurs

Piaopiao Pan (P)

Centre for the Cellular Microenvironment, School of Molecular Biology, University of Glasgow, Glasgow, UK.

Yilin Wang (Y)

Department of Bacteriology and Immunology, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, China.

Mukanthu H Nyirenda (MH)

Institute of Infection and Immunity, University of Glasgow, Glasgow, UK.
Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Zainulabedin Saiyed (Z)

Research and Development, Lonza Greenwood LLC, North Emerald Road, Greenwood, SC, USA.

Elnaz Karimian Azari (E)

Research and Development, Lonza Greenwood LLC, North Emerald Road, Greenwood, SC, USA.

Amy Sunderman (A)

Research and Development, Lonza Greenwood LLC, North Emerald Road, Greenwood, SC, USA.

Simon Milling (S)

Institute of Infection and Immunity, University of Glasgow, Glasgow, UK.

Margaret M Harnett (MM)

Institute of Infection and Immunity, University of Glasgow, Glasgow, UK.

Miguel Pineda (M)

Centre for the Cellular Microenvironment, School of Molecular Biology, University of Glasgow, Glasgow, UK. miguel.pineda@glasgow.ac.uk.

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