Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
03 Jul 2024
03 Jul 2024
Historique:
received:
29
09
2023
accepted:
12
06
2024
medline:
4
7
2024
pubmed:
4
7
2024
entrez:
3
7
2024
Statut:
epublish
Résumé
Developmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF are eliminated by around postnatal day 20. Heterosynaptic interaction between CFs and parallel fibers (PFs), the axons of cerebellar granule cells (GCs) forming excitatory synapses onto PCs and molecular layer interneurons (MLIs), is crucial for CF synapse elimination. However, mechanisms for this heterosynaptic interaction are largely unknown. Here we show that deletion of AMPA-type glutamate receptor functions in GCs impairs CF synapse elimination mediated by metabotropic glutamate receptor 1 (mGlu1) signaling in PCs. Furthermore, CF synapse elimination is impaired by deleting NMDA-type glutamate receptors from MLIs. We propose that PF activity is crucial for CF synapse elimination by directly activating mGlu1 in PCs and indirectly enhancing the inhibition of PCs through activating NMDA receptors in MLIs.
Identifiants
pubmed: 38961250
doi: 10.1038/s42003-024-06447-4
pii: 10.1038/s42003-024-06447-4
doi:
Substances chimiques
Receptors, Metabotropic Glutamate
0
metabotropic glutamate receptor type 1
0
Receptors, AMPA
0
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
806Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 18H04012
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 21H04785
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20H05915
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20K06862
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20H05916
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 16H06276
Informations de copyright
© 2024. The Author(s).
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