Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
04 Jul 2024
Historique:
medline: 4 7 2024
pubmed: 4 7 2024
entrez: 4 7 2024
Statut: aheadofprint

Résumé

Inherited retinal diseases, which include retinitis pigmentosa, are a family of genetic disorders characterized by gradual rod-cone degeneration and vision loss, without effective pharmacological treatments. Experimental approaches aim to delay disease progression, supporting cones' survival, crucial for human vision. Histone deacetylases (HDACs) mediate the activation of epigenetic and nonepigenetic pathways that modulate cone degeneration in RP mouse models. We developed new HDAC inhibitors (

Identifiants

DOI: 10.1021/acs.jmedchem.4c00477 PMID: 38961727
pubmed: 38961727
doi: 10.1021/acs.jmedchem.4c00477
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Gabriele Carullo (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-1619-3295

Noemi Orsini (N)

Neuroscience Institute, Italian National Research Council (CNR) Area della Ricerca, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Regional Doctorate School in Neuroscience of Universities of Florence, Pisa, Siena, Florence, CNR Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.

Ilaria Piano (I)

Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy.

Luca Pozzetti (L)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-0035-4621

Alessandro Papa (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Anna Fontana (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Debora Napoli (D)

Neuroscience Institute, Italian National Research Council (CNR) Area della Ricerca, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Regional Doctorate School in Neuroscience of Universities of Florence, Pisa, Siena, Florence, CNR Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.

Francesca Corsi (F)

Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy.

Beatrice Di Marco (BD)

Neuroscience Institute, Italian National Research Council (CNR) Area della Ricerca, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.
Regional Doctorate School in Neuroscience of Universities of Florence, Pisa, Siena, Florence, CNR Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.

Alessia Galante (A)

Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy.

Ludovica Marotta (L)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Giovanna Panzeca (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0001-6479-7686

Justine O'Brien (J)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.

Alicia Gomez Sanchez (AG)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.

Harry Doherty (H)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.

Niamh Mahon (N)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.

Leni Clarke (L)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.

Chiara Contri (C)

Department of Translational Medicine, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

Silvia Pasquini (S)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

Beatrice Gorelli (B)

Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Simona Saponara (S)

Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Massimo Valoti (M)

Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.

Fabrizio Vincenzi (F)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

Katia Varani (K)

Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy.

Anna Ramunno (A)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84100 Fisciano (SA), Italy.
ORCID: 0000-0003-1089-2439

Simone Brogi (S)

Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy.
ORCID: 0000-0001-9375-6242

Stefania Butini (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-8471-0880

Sandra Gemma (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-8313-2417

Breandán N Kennedy (BN)

UCD School of Biomolecular and Biomedical Science and UCD Conway Institute, University College Dublin, D04 V1W8 Dublin, Ireland.
ORCID: 0000-0001-7991-4689

Claudia Gargini (C)

Department of Pharmacy, Via Bonanno 6, 56124 Pisa, Italy.

Enrica Strettoi (E)

Neuroscience Institute, Italian National Research Council (CNR) Area della Ricerca, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy.

Giuseppe Campiani (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran.
ORCID: 0000-0001-5295-9529

Classifications MeSH