Basal release of 6-cyanodopamine from rat isolated vas deferens and its role on the tissue contractility.
S100
ejaculation
high performance liquid chromatography
smooth muscle tonus
synergism
tandem mass spectrometry
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
04 Jul 2024
04 Jul 2024
Historique:
received:
14
05
2024
accepted:
24
06
2024
revised:
22
06
2024
medline:
4
7
2024
pubmed:
4
7
2024
entrez:
4
7
2024
Statut:
aheadofprint
Résumé
6-Cyanodopamine is a novel catecholamine released from rabbit isolated heart. However, it is not known whether this catecholamine presents any biological activity. Here, it was evaluated whether 6-cyanodopamine (6-CYD) is released from rat vas deferens and its effect on this tissue contractility. Basal release of 6-CYD, 6-nitrodopamine (6-ND), 6-bromodopamine, 6-nitrodopa, and 6-nitroadrenaline from vas deferens were quantified by LC-MS/MS. Electric-field stimulation (EFS) and concentration-response curves to noradrenaline, adrenaline, and dopamine of the rat isolated epididymal vas deferens (RIEVD) were performed in the absence and presence of 6-CYD and /or 6-ND. Expression of tyrosine hydroxylase was assessed by immunohistochemistry. The rat isolated vas deferens released significant amounts of both 6-CYD and 6-ND. The voltage-gated sodium channel blocker tetrodotoxin had no effect on the release of 6-CYD, but it virtually abolished 6-ND release. 6-CYD alone exhibited a negligible RIEVD contractile activity; however, at 10 nM, 6-CYD significantly potentiated the noradrenaline- and EFS-induced RIEVD contractions, whereas at 10 and 100 nM, it also significantly potentiated the adrenaline- and dopamine-induced contractions. The potentiation of noradrenaline- and adrenaline-induced contractions by 6-CYD was unaffected by tetrodotoxin. Co-incubation of 6-CYD (100 pM) with 6-ND (10 pM) caused a significant leftward shift and increased the maximal contractile responses to noradrenaline, even in the presence of tetrodotoxin. Immunohistochemistry revealed the presence of tyrosine hydroxylase in both epithelial cell cytoplasm of the mucosae and nerve fibers of RIEVD. The identification of epithelium-derived 6-CYD and its remarkable synergism with catecholamines indicate that epithelial cells may regulate vas deferens smooth muscle contractility.
Identifiants
pubmed: 38963545
doi: 10.1007/s00424-024-02985-2
pii: 10.1007/s00424-024-02985-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Aboud R, Shafii M, Docherty JR (1993) Investigation of the subtypes of alpha 1-adrenoceptor mediating contractions of rat aorta, vas deferens and spleen. Br J Pharmacol 109(1):80–87. https://doi.org/10.1111/j.1476-5381.1993.tb13534.x
doi: 10.1111/j.1476-5381.1993.tb13534.x
pubmed: 8098642
pmcid: 2175602
Amobi NI, Chung IP, Smith IC (2006) Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors. Auton Autacoid Pharmacol 26(2):169–181. https://doi.org/10.1111/j.1474-8673.2006.00367.x
doi: 10.1111/j.1474-8673.2006.00367.x
pubmed: 16553645
Andersen ML. Normativas do CONCEA para a Produção, Manutenção ou Utilização Animal em atividades de Ensino ou Pesquisa Científica. Leis, Decretos, Portarias, Resoluções Normativas e Orientações técnicas. 3ª Edição. Brasília, v. 26, 2016.
Anseeuw K, Delvau N, Burillo-Putze G, De Iaco F, Geldner G, Holmström P, Lambert Y, Sabbe M (2013) Cyanide poisoning by fire smoke inhalation: a European expert consensus. Eur J Emerg Med 20(1):2–9. https://doi.org/10.1097/MEJ.0b013e328357170b
doi: 10.1097/MEJ.0b013e328357170b
pubmed: 22828651
Anton PG, McGrath JC (1977) Further evidence for adrenergic transmission in the human vas deferens. J Physiol 273(1):45–55. https://doi.org/10.1113/jphysiol.1977.sp012080
doi: 10.1113/jphysiol.1977.sp012080
pubmed: 23430
pmcid: 1353725
Basile B, Lazcano A, Oró J (1984) Prebiotic syntheses of purines and pyrimidines. Adv Space Res 4(12):125–131. https://doi.org/10.1016/0273-1177(84)90554-4
doi: 10.1016/0273-1177(84)90554-4
pubmed: 11537766
Baskin SI, Brewer TG (1997) Cyanide Poisoning, in Medical Aspects of Chemical and Biological Warfare. In: Zajtchuk R, Bellamy RF, Sidell FR, Takefugi ET, Franz DR (eds) Office of the Surgeon General. Department of the Army, United States, pp 271–286
Bönisch H, Trendelenburg U. The mechanism of action of indirectly acting sympathomimetic amines. In: Trendelenburg U, Weiner N (eds) Catecholamines - Handbook of experimental pharmacology. Springer, Berlin Heidelberg New York, 1988; 90(1) 247 – 277
Bradley AB, Morgan KG (1987) Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin. J Physiol 385:437–448. https://doi.org/10.1113/jphysiol.1987.sp016500
doi: 10.1113/jphysiol.1987.sp016500
pubmed: 3477639
pmcid: 1192353
Britto-Júnior J, da Silva-Filho WP, Amorim AC, Campos R, Moraes MO, Moraes MEA, Fregonesi A, Monica FZ, Antunes E, De Nucci G (2022a) 6-nitrodopamine is a major endogenous modulator of human vas deferens contractility. Andrology 10(8):1540–1547. https://doi.org/10.1111/andr.13263
doi: 10.1111/andr.13263
pubmed: 35934935
Britto-Júnior J, Lima AT, Campos R, Gião AA, Mendes GD, Ferreira-Novaes Silva LP, Fregonesi A, Pupo AS, Antunes E, De Nucci G (2023a) 6-Nitrodopamine potentiates contractions of rat isolated vas deferens induced by noradrenaline, adrenaline, dopamine and electric field stimulation. Naunyn Schmiedeberg's Arch Pharmacol 396(10):2555–2570. https://doi.org/10.1007/s00210-023-02478-6
doi: 10.1007/s00210-023-02478-6
Britto-Júnior J, Lima AT, Fuguhara V, Monica FZ, Antunes E, De Nucci G (2023b) Investigation on the positive chronotropic action of 6-nitrodopamine in the rat isolated atria. Naunyn Schmiedeberg's Arch Pharmacol 396(6):1279–1290. https://doi.org/10.1007/s00210-023-02394-9
doi: 10.1007/s00210-023-02394-9
Britto-Júnior J, Nacário Silva SG, Lima AT, Fuguhara V, Andrade LB, Mendes GD, Peterson LW, Chiavegatto S, Antunes E, De Nucci G (2024a) The pivotal role of neuronal nitric oxide synthase in the release of 6-nitrodopamine from mouse isolated vas deferens. Nitric Oxide 143:1–8. https://doi.org/10.1016/j.niox.2023.12.002
doi: 10.1016/j.niox.2023.12.002
pubmed: 38096948
Britto-Júnior J, Pinheiro DHA, Justo AFO, Figueiredo Murari GM, Campos R, Mariano FV, de Souza VB, Schenka AA, Mónica FZ, Antunes E, De Nucci G (2020) Endothelium-derived dopamine modulates EFS-induced contractions of human umbilical vessels. Pharmacol Res Perspect 8(4):e00612. https://doi.org/10.1002/prp2.612
doi: 10.1002/prp2.612
pubmed: 32567793
pmcid: 7307250
Britto-Júnior J, Ribeiro A, Ximenes L, Lima AT, Jacintho FF, Fregonesi A, Mónica FZ, Antunes E, De Nucci G (2022b) Alpha1-adrenergic antagonists block 6-nitrodopamine contractions on the rat isolated epididymal vas deferens. Eur J Pharmacol 915:174716. https://doi.org/10.1016/j.ejphar.2021.174716
doi: 10.1016/j.ejphar.2021.174716
pubmed: 34951979
Britto-Júnior J, Uramoto EHS, Lima AT, Ribeiro LF, de Souza VB, Schenka AA, de Almeida Magalhães JC, Antunes E, Fregonesi A, De Nucci G (2024) Epithelium-derived 6-nitrodopamine modulates noradrenaline-induced contractions in human seminal vesicles. Life Sci 348:122695. https://doi.org/10.1016/j.lfs.2024.122695
doi: 10.1016/j.lfs.2024.122695
pubmed: 38710285
Britto-Júnior J, Ximenes L, Ribeiro A, Fregonesi A, Campos R, Ricardo de Almeida Kiguti L, Mónica FZ, Antunes E, De Nucci G (2021a) 6-Nitrodopamine is an endogenous mediator of rat isolated epididymal vas deferens contractions induced by electric-field stimulation. Eur J Pharmacol 911:174544. https://doi.org/10.1016/j.ejphar.2021.174544
doi: 10.1016/j.ejphar.2021.174544
pubmed: 34606837
Burnstock G (1986) Autonomic neuromuscular junctions: current developments and future directions. J Anat 146:1–30
pubmed: 3319994
pmcid: 1166521
Burnstock G (1995) Noradrenaline and ATP: cotransmitters and neuromodulators. J Physiol Pharmacol 46(4):365–384
pubmed: 8770783
Canessa De Scarnati O, Lapetina EG (1974) Adrenergic stimulation of phosphatidylinositol label- ling in rat vas deferens. Biochim Biophys Acta 360:298–305
doi: 10.1016/0005-2760(74)90059-9
pubmed: 4369760
Elbadawi A, Goodman DC (1980) Autonomic innervation of accessory male genital glands. Male accessory sex glands:101–128
Elwan MA, Thangavel R, Ono F, Sakuragawa N (1998) Synthesis and release of catecholamines by cultured monkey amniotic epithelial cells. J Neurosci Res 53(1):107–113. https://doi.org/10.1002/(SICI)1097-4547(19980701)53:1<107::AID-JNR11>3.0.CO;2-6
doi: 10.1002/(SICI)1097-4547(19980701)53:1<107::AID-JNR11>3.0.CO;2-6
pubmed: 9670997
Fasco MJ, Stack RF, Lu S, Hauer CR 3rd, Schneider E, Dailey M, Aldous KM (2011) Unique cyanide adduct in human serum albumin: potential as a surrogate exposure marker. Chem Res Toxicol 24(4):505–514. https://doi.org/10.1021/tx100344e
doi: 10.1021/tx100344e
pubmed: 21366342
pmcid: 3089968
Foley KF, Cozzi NV (2002) Inhibition of transport function and desipramine binding at the human noradrenaline transporter by N-ethylmaleimide and protection by substrate analogs. Naunyn Schmiedeberg's Arch Pharmacol 365(6):457–461. https://doi.org/10.1007/s00210-002-0532-3
doi: 10.1007/s00210-002-0532-3
Fox AW, Abel PW, Minneman KP (1985) Activation of alpha 1-adrenoceptors increases [3H] inositol metabolism in rat vas deferens and caudal artery. Eur J Pharmacol 116(1-2):145–152. https://doi.org/10.1016/0014-2999(85)90195-5
doi: 10.1016/0014-2999(85)90195-5
pubmed: 2865157
Hay DW, Wadsworth RM (1984) Effects of KCl on 45Ca uptake and efflux in the rat vas deferens. Br J Pharmacol 81(3):441–447. https://doi.org/10.1111/j.1476-5381.1984.tb10096.x
doi: 10.1111/j.1476-5381.1984.tb10096.x
pubmed: 6697058
pmcid: 1986861
Illes P, Meier C, Starke K (1984) Tetrodotoxin-resistant release of 3H-noradrenaline from the mouse vas deferens by high intensity electrical stimulation. Neuroscience 11(3):715–721. https://doi.org/10.1016/0306-4522(84)90054-x
doi: 10.1016/0306-4522(84)90054-x
pubmed: 6717806
Júnior GQ, Britto-Júnior J, Magalhaes TB, Campos R, Nyamkondiwa KL, Klugh KL, Peterson LW, Corvino A, Sparaco R, Frecentese F, Caliendo G, De Nucci G (2023) Measurement of 6-cyanodopamine, 6-nitrodopa, 6-nitrodopamine and 6-nitroadrenaline by LC-MS/MS in Krebs-Henseleit solution. Assessment of basal release from rabbit isolated right atrium and ventricles. Biomed Chromatogr 37(9):e5691. https://doi.org/10.1002/bmc.5691
doi: 10.1002/bmc.5691
pubmed: 37431086
Kakishita K, Elwan MA, Nakao N, Itakura T, Sakuragawa N (2000) Human amniotic epithelial cells produce dopamine and survive after implantation into the striatum of a rat model of Parkinson's disease: a potential source of donor for transplantation therapy. Exp Neurol 165(1):27–34. https://doi.org/10.1006/exnr.2000.7449
doi: 10.1006/exnr.2000.7449
pubmed: 10964482
Kawada T, Yamazaki T, Akiyama T, Sato T, Shishido T, Inagaki M, Tatewaki T, Yanagiya Y, Sugimachi M, Sunagawa K (2000) Cyanide intoxication induced exocytotic epinephrine release in rabbit myocardium. J Auton Nerv Syst 80(3):137–141. https://doi.org/10.1016/s0165-1838(00)00086-2
doi: 10.1016/s0165-1838(00)00086-2
pubmed: 10785279
Kitazawa T, Masuo M, Somlyo AP (1991) G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc Natl Acad Sci USA 88(20):9307–9310. https://doi.org/10.1073/pnas.88.20.9307
doi: 10.1073/pnas.88.20.9307
pubmed: 1656467
pmcid: 52703
Kurz T, Richardt G, Hagl S, Seyfarth M, Schömig A (1995) Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue. J Mol Cell Cardiol 27(5):1161–1172. https://doi.org/10.1016/0022-2828(95)90052-7
doi: 10.1016/0022-2828(95)90052-7
pubmed: 7473774
Lewis JL, Rhoades CE, Gervasi PG, Griffith WC, Dahl AR (1991) The cyanide-metabolizing enzyme rhodanese in human nasal respiratory mucosa. Toxicol Appl Pharmacol 108(1):114–120. https://doi.org/10.1016/0041-008x(91)90274-i
doi: 10.1016/0041-008x(91)90274-i
pubmed: 2006499
Lima AT, Amorim AC, Britto-Júnior J, Campitelli RR, Fregonesi A, Mónica FZ, Antunes E, De Nucci G (2022) β
doi: 10.1007/s00210-022-02268-6
Matthews CN, Minard RD (2006) Hydrogen cyanide polymers, comets and the origin of life. Faraday Discuss 133:393–401. https://doi.org/10.1039/b516791d
doi: 10.1039/b516791d
pubmed: 17191459
Ming M, Li X, Fan X, Yang D, Li L, Chen S, Gu Q, Le W (2009) Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson's disease. J Transl Med 7:53. https://doi.org/10.1186/1479-5876-7-53
doi: 10.1186/1479-5876-7-53
pubmed: 19558709
pmcid: 2709608
Mitchell JA, Sheng H, Förstermann U, Murad F (1991) Characterization of nitric oxide synthases in non-adrenergic non-cholinergic nerve containing tissue from the rat anococcygeus muscle. Br J Pharmacol 104(2):289–291. https://doi.org/10.1111/j.1476-5381.1991.tb12422.x
doi: 10.1111/j.1476-5381.1991.tb12422.x
pubmed: 1724623
pmcid: 1908579
Morellini N, Phillips JK, Wall RV, Drummond PD (2019) Expression of the noradrenaline transporter in the peripheral nervous system. J Chem Neuroanat 104:101742. https://doi.org/10.1016/j.jchemneu.2019.101742
doi: 10.1016/j.jchemneu.2019.101742
pubmed: 31891756
Mullaney I, Carr IC, Burt AR, Wilson M, Anderson NG, Milligan G (1997) Agonist-mediated tyrosine phosphorylation of isoforms of the shc adapter protein by the delta opioid receptor. Cell Signal 9(6):423–429. https://doi.org/10.1016/s0898-6568(96)00188-x
doi: 10.1016/s0898-6568(96)00188-x
pubmed: 9376223
Muramatsu I, Oshita M, Ohmura T, Kigoshi S, Akino H, Gobara M, Okada K (1994) Pharmacological characterization of alpha 1-adrenoceptor subtypes in the human prostate: functional and binding studies. Br J Urol 74(5):572–578. https://doi.org/10.1111/j.1464-410x.1994.tb09186.x
doi: 10.1111/j.1464-410x.1994.tb09186.x
pubmed: 7530120
Nyamkondiwa K, Squires T, Jones P, Colabroy KL, Peterson LW (2022) Insight into L-DOPA dioxygenase mechanism with 6-substituted L-DOPA derivatives. FASEB J 36(S1)
Oro J, Kamat SS (1961) Amino-acid synthesis from hydrogen cyanide under possible primitive earth conditions. Nature 190:442–443. https://doi.org/10.1038/190442a0
doi: 10.1038/190442a0
pubmed: 13731262
Park BK, Haynes BP, Sheridan SA, Nowell PT (1983) Stereoselectivity of catecholamines: differential effects of cocaine and desipramine on catecholamine-induced contractions of the rat isolated vas deferens. J Pharm Pharmacol 35(6):373–377. https://doi.org/10.1111/j.2042-7158.1983.tb02959.x
doi: 10.1111/j.2042-7158.1983.tb02959.x
pubmed: 6135776
Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, CJ MC, Macleod M et al (2020) The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research. PLoS Biol 18(7):e3000410. https://doi.org/10.1371/journal.pbio.3000410
doi: 10.1371/journal.pbio.3000410
pubmed: 32663219
pmcid: 7360023
Ribeiro LF, Babadopulos T, Oliveira MG, Nishimaru F, Zatz R, Elias RM, Moraes O, Moraes E, Peterson LW, De Nucci G (2024) A LC-MS/MS method for the simultaneous determination of 6-cyanodopamine, 6-nitrodopamine, 6-nitrodopa, 6-nitroadrenaline, and 6-bromodopamine in human plasma and its clinical application in patients with chronic kidney disease. Biomed Chromatogr
Rickert WS, Robinson JC, Young JC (1980) Estimating the hazards of "less hazardous" cigarettes. I. Tar, nicotine, carbon monoxide, acrolein, hydrogen cyanide, and total aldehyde deliveries of Canadian cigarettes. J Toxicol Environ Health 6(2):351–365. https://doi.org/10.1080/15287398009529856
doi: 10.1080/15287398009529856
pubmed: 6248649
Rote JC, Malkowski SN, Cochrane CS, Bailey GE, Brown NS, Cafiero M, Peterson LW (2017) Catechol reactivity: Synthesis of dopamine derivatives substituted at the 6-position. Synth Commun 47(5):435–441
doi: 10.1080/00397911.2016.1269350
Rubin RP (1970) The role of calcium in the release of neurotransmitter substances and hormones. Pharmacol Rev 22(3):389–428
pubmed: 4322219
Schömig A, Fischer S, Kurz T, Richardt G, Schömig E (1987) Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements. Circ Res 60(2):194–205. https://doi.org/10.1161/01.res.60.2.194
doi: 10.1161/01.res.60.2.194
pubmed: 3568291
Schömig E, Schönfeld CL, Halbrügge T, Graefe KH, Trendelenburg U (1990) The heterogeneity of the neuronal distribution of exogenous noradrenaline in the rat vas deferens. Naunyn Schmiedeberg's Arch Pharmacol 342(2):160–170. https://doi.org/10.1007/BF00166959
doi: 10.1007/BF00166959
Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD (2000) Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. J Comp Neurol 420(2):211–232
doi: 10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3
pubmed: 10753308
Somlyo AP, Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature 372(6503):231–236. https://doi.org/10.1038/372231a0
doi: 10.1038/372231a0
pubmed: 7969467
Steers WD (1994) Physiology of the vas deferens. World J Urol 12(5):281–285. https://doi.org/10.1007/BF00191208
doi: 10.1007/BF00191208
pubmed: 7532517
Swedin G, Lindholmer C (1974) Permanent infertility of the male rat after denervation of the vas deferens and the accessory genital glands. Andrologia 6(2):103–110. https://doi.org/10.1111/j.1439-0272.1974.tb01602.x
doi: 10.1111/j.1439-0272.1974.tb01602.x
pubmed: 4417743
Uwakwe AA, Monanu MO, Anosike EO (1991) Whole blood cyanide levels of mainly dietary origin in a human population sample in Port Harcourt. Nigeria Plant Foods Hum Nutr 41(2):117–124. https://doi.org/10.1007/BF02194080
doi: 10.1007/BF02194080
pubmed: 1852725
Veith RC, Lewis N, Linares OA, Barnes RF, Raskind MA, Villacres EC, Murburg MM, Ashleigh EA, Castillo S, Peskind ER et al (1994) Sympathetic nervous system activity in major depression. Basal and desipramine-induced alterations in plasma norepinephrine kinetics. Arch Gen Psychiatry 51(5):411–422. https://doi.org/10.1001/archpsyc.1994.03950050071008
doi: 10.1001/archpsyc.1994.03950050071008
pubmed: 8179465
Witcher DR, De Waard M, Campbell KP (1993) Characterization of the purified N-type Ca2+ channel and the cation sensitivity of omega-conotoxin GVIA binding. Neuropharmacology 32(11):1127–1139. https://doi.org/10.1016/0028-3908(93)90007-p
doi: 10.1016/0028-3908(93)90007-p
pubmed: 8107967
Young MA (1965) Health Hazards Of Electroplating. J Occup Med 7:348–352. https://doi.org/10.1097/00043764-196507000-00008
doi: 10.1097/00043764-196507000-00008
pubmed: 14321464
Zatz R, De Nucci G (2024) Endothelium-Derived Dopamine and 6-Nitrodopamine in the Cardiovascular System. Physiology (Bethesda) 39(1):44–59. https://doi.org/10.1152/physiol.00020.2023
doi: 10.1152/physiol.00020.2023
pubmed: 37874898