CNV DNA-seq MT: Regular Issue PDX mouse model cfDNA copy number variation ctDNA liquid biopsy p14ARF p16INK4A prognosis

Journal

Molecular therapy. Oncology
ISSN: 2950-3299
Titre abrégé: Mol Ther Oncol
Pays: United States
ID NLM: 9918752083706676

Informations de publication

Date de publication:
20 Jun 2024
Historique:
received: 09 10 2023
revised: 20 03 2024
accepted: 22 05 2024
medline: 5 7 2024
pubmed: 5 7 2024
entrez: 5 7 2024
Statut: epublish

Résumé

Bladder cancer (BlCa) is an extensively heterogeneous disease that leads to great variability in tumor evolution scenarios and lifelong patient surveillance, emphasizing the need for modern, minimally invasive precision medicine. Here, we explored the clinical significance of copy number alterations (CNAs) in BlCa. CNA profiling was performed in 15 patient-derived xenografts (PDXs) and validated in The Cancer Genome Atlas BlCa (TCGA-BLCA;

Identifiants

DOI: 10.1016/j.omton.2024.200818 PMID: 38966038 PMC: PMC11223115
pubmed: 38966038
doi: 10.1016/j.omton.2024.200818
pii: S2950-3299(24)00060-2
pmc: PMC11223115
doi:

Types de publication

Journal Article

Langues

eng

Pagination

200818

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Maria-Alexandra Papadimitriou (MA)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Katerina-Marina Pilala (KM)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Konstantina Panoutsopoulou (K)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Panagiotis Levis (P)

First Department of Urology, "Laiko" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.

Georgios Kotronopoulos (G)

First Department of Urology, "Laiko" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.

Zoi Kanaki (Z)

Biomedical Research Foundation Academy of Athens, Athens, Greece.

Gedeon Loules (G)

CeMIA SA, Larissa, Greece.

Maria Zamanakou (M)

CeMIA SA, Larissa, Greece.

Dimitrios Linardoutsos (D)

First Department of Propaedeutic Surgery, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Diamantis C Sideris (DC)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Konstantinos Stravodimos (K)

First Department of Urology, "Laiko" General Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece.

Apostolos Klinakis (A)

Biomedical Research Foundation Academy of Athens, Athens, Greece.

Andreas Scorilas (A)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.

Margaritis Avgeris (M)

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Laboratory of Clinical Biochemistry - Molecular Diagnostics, Second Department of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, Athens, Greece.

Classifications MeSH