Human CD56

CD56+CD39+ dNK subset M-CSF NOG mice adoptive transfer placental trophoblast cell fate recurrent pregnancy loss

Journal

National science review
ISSN: 2053-714X
Titre abrégé: Natl Sci Rev
Pays: China
ID NLM: 101633095

Informations de publication

Date de publication:
Jun 2024
Historique:
received: 11 09 2023
revised: 26 03 2024
accepted: 04 04 2024
medline: 5 7 2024
pubmed: 5 7 2024
entrez: 5 7 2024
Statut: epublish

Résumé

Decidual natural killer (dNK) cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss (RPL) at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG (NOD/Shi-

Identifiants

DOI: 10.1093/nsr/nwae142 PMID: 38966071 PMC: PMC11223582
pubmed: 38966071
doi: 10.1093/nsr/nwae142
pii: nwae142
pmc: PMC11223582
doi:

Types de publication

Journal Article

Langues

eng

Pagination

nwae142

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

Auteurs

Wentong Jia (W)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Liyang Ma (L)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Xin Yu (X)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
University of the Chinese Academy of Sciences, Beijing 101408, China.
ORCID: 0000-0003-0314-9030

Feiyang Wang (F)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
University of the Chinese Academy of Sciences, Beijing 101408, China.
ORCID: 0000-0002-7866-5497

Qian Yang (Q)

NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China.

Xiaoye Wang (X)

National Clinical Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Mengjie Fan (M)

National Clinical Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Yan Gu (Y)

Department of Family Planning, The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

Ran Meng (R)

Department of Prenatal Screening, Haidian Maternal and Child Health Hospital, Beijing 100080, China.

Jian Wang (J)

NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China.

Yuxia Li (Y)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Rong Li (R)

National Clinical Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
ORCID: 0000-0003-0305-5579

Xuan Shao (X)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
University of the Chinese Academy of Sciences, Beijing 101408, China.
ORCID: 0000-0003-0352-1648

Yan-Ling Wang (YL)

State Key Laboratory of Stem cell and Reproductive Biology, Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
University of the Chinese Academy of Sciences, Beijing 101408, China.
ORCID: 0000-0002-9448-7803

Classifications MeSH