Detecting Amyloid Goiter With 99mTc-PYP SPECT/CT in the Setting of Ankylosing Spondylitis: An Uncommon Involvement of AA Amyloidosis.


Journal

Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109

Informations de publication

Date de publication:
01 Aug 2024
Historique:
medline: 5 7 2024
pubmed: 5 7 2024
entrez: 5 7 2024
Statut: ppublish

Résumé

We present a case with systemic amyloidosis secondary to ankylosing spondylitis (AA amyloidosis), whose 99mTc PYP scintigraphy revealed amyloid deposition in the thyroid gland (amyloid goiter). Amyloidosis is characterized by extracellular accumulation of amyloid fibril proteins leading to organ malfunction. Even though AA amyloidosis can be observed in patients with systemic inflammatory diseases, it is a very rare complication in ankylosing spondylitis. SPECT/CT images showed diffuse tracer uptake in enlarged thyroid gland containing fat density areas.

Identifiants

pubmed: 38967510
doi: 10.1097/RLU.0000000000005280
pii: 00003072-202408000-00031
doi:

Substances chimiques

Technetium Tc 99m Pyrophosphate 5L76I61H2B

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e399-e400

Informations de copyright

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of interest and sources of funding: none declared.

Références

Zhu W, He X, Cheng K, et al. Ankylosing spondylitis: etiology, pathogenesis, and treatments. Bone Res. 2019;7:22.
Kridin M, Kridin K, Cohen AD, et al. The risk, predictors and outcomes of amyloidosis in ankylosing spondylitis: a longitudinal population-based cohort study. Rheumatology (Oxford). 2022;61:2072–2078.
Dönmez S, Pamuk ÖN, Pamuk GE, et al. Secondary amyloidosis in ankylosing spondylitis. Rheumatol Int. 2013;33:1725–1729.
Leinonen H, Tötterman KJ, Korppi-Tommola T, et al. Negative myocardial technetium-99m pyrophosphate scintigraphy in amyloid heart disease associated with type AA systemic amyloidosis. Am J Cardiol. 1984;53:380–381.
Dorbala S, Ando Y, Bokhari S, et al. ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 1 of 2-evidence base and standardized methods of imaging. Circ Cardiovasc Imaging. 2021;14:e000029.
Masri A, Bukhari S, Eisele YS, et al. Molecular imaging of cardiac amyloidosis. J Nucl Med. 2020;61:965–970.
Vergneault H, Terré A, Buob D, et al. Amyloid goiter in familial Mediterranean fever: description of 42 cases from a French cohort and from literature review. J Clin Med. 2021;10.
Lee VW, Rubinow A, Pehrson J, et al. Amyloid goiter: preoperative scintigraphic diagnosis using Tc-99m pyrophosphate. J Nucl Med. 1984;25:468–471.
Lari E, Burhamah W, Lari A, et al. Amyloid goiter—a rare case report and literature review. Ann Med Surg (Lond). 2020;57:295–298.
Bakan S, Kandemirli SG, Akbas S, et al. Amyloid goiter: a diagnosis to consider in diffuse fatty infiltration of the thyroid. J Ultrasound Med. 2017;36:1045–1049.
Law JH, Dean DS, Scheithauer B, et al. Symptomatic amyloid goiters: report of five cases. Thyroid. 2013;23:1490–1495.

Auteurs

Dilara Denizmen (D)

From the Departments of Nuclear Medicine.

Dogu Vuralli Bakkaloglu (DV)

Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.

Duygu Has Simsek (DH)

From the Departments of Nuclear Medicine.

Yasemin Sanli (Y)

From the Departments of Nuclear Medicine.

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