Pro-survival signaling regulates lipophagy essential for multiple myeloma resistance to stress-induced death.
CD28
CP: Cancer
CP: Metabolism
autophagy
fatty acid metabolism
fatty acid oxidation
lipid droplets
lipophagy
multiple myeloma
pro-survival regulation
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
03 Jul 2024
03 Jul 2024
Historique:
received:
01
08
2023
revised:
27
05
2024
accepted:
20
06
2024
medline:
5
7
2024
pubmed:
5
7
2024
entrez:
5
7
2024
Statut:
aheadofprint
Résumé
Pro-survival metabolic adaptations to stress in tumorigenesis remain less well defined. We find that multiple myeloma (MM) is unexpectedly dependent on beta-oxidation of long-chain fatty acids (FAs) for survival under both basal and stress conditions. However, under stress conditions, a second pro-survival signal is required to sustain FA oxidation (FAO). We previously found that CD28 is expressed on MM cells and transduces a significant pro-survival/chemotherapy resistance signal. We now find that CD28 signaling regulates autophagy/lipophagy that involves activation of the Ca
Identifiants
pubmed: 38968073
pii: S2211-1247(24)00774-5
doi: 10.1016/j.celrep.2024.114445
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114445Informations de copyright
Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.