tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 Jul 2024
05 Jul 2024
Historique:
received:
18
02
2024
accepted:
20
06
2024
medline:
6
7
2024
pubmed:
6
7
2024
entrez:
5
7
2024
Statut:
epublish
Résumé
Investigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used bioluminescence resonance energy transfer (BRET) assays including NanoBRET, time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays are not easily accessible to the research community. We created tracerDB, a curated database of validated tracers. This resource provides an open access knowledge base and a unified system for tracer and assay validation. The database is freely available at https://www.tracerdb.org/ .
Identifiants
pubmed: 38969708
doi: 10.1038/s41467-024-49896-5
pii: 10.1038/s41467-024-49896-5
doi:
Substances chimiques
Fluorescent Dyes
0
Ligands
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5646Subventions
Organisme : Deutsche Forschungsgemeinschaft (German Research Foundation)
ID : 424228829
Informations de copyright
© 2024. The Author(s).
Références
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