Effects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review.
Dosage
Fitness
Mg
Micronutrient
Physical activity
Physical performance
Journal
Journal of translational medicine
ISSN: 1479-5876
Titre abrégé: J Transl Med
Pays: England
ID NLM: 101190741
Informations de publication
Date de publication:
05 Jul 2024
05 Jul 2024
Historique:
received:
22
05
2024
accepted:
23
06
2024
medline:
6
7
2024
pubmed:
6
7
2024
entrez:
5
7
2024
Statut:
epublish
Résumé
Magnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production and storage, control of neuronal and vasomotor activity, cardiac excitability, and muscle contraction. Magnesium deficiency may result in impaired physical performance. Moreover, magnesium plays an important role on delayed onset muscle soreness after training. Thus, physically active individuals and sport specialists have to pay attention to magnesium supplementation (MgS). However, the type, timing and dosage of magnesium intake are not well elucidated yet. Hence, we aimed to systematically review the literature regarding the effects of MgS on muscle soreness in physically active individuals. We focused exclusively on MgS, excluding those studies in which magnesium was administered together with other substances. Three electronic databases and literature sources (PUBMED, SCOPUS and Web of Sciences-Core Collection) were searched, in accordance with PRISMA guidelines. After the database search, 1254 articles were identified, and after excluding duplicates, 960 articles remained. Among these, 955 were excluded following the title and abstract screening. The remaining 5 articles were screened in full text and 4 study met the eligibility criteria. These studies showed that MgS reduced muscle soreness, improved performance, recovery and induced a protective effect on muscle damage. To reach these positive effects, individuals engaged in intense exercise should have a Mg requirement 10-20% higher than sedentary people, to be taken in capsules and 2 h before training. Moreover, it is suggested to maintain magnesium levels in the recommended range during the off-season. PROSPERO registration number: CRD42024501822.
Sections du résumé
BACKGROUND
BACKGROUND
Magnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production and storage, control of neuronal and vasomotor activity, cardiac excitability, and muscle contraction. Magnesium deficiency may result in impaired physical performance. Moreover, magnesium plays an important role on delayed onset muscle soreness after training. Thus, physically active individuals and sport specialists have to pay attention to magnesium supplementation (MgS). However, the type, timing and dosage of magnesium intake are not well elucidated yet. Hence, we aimed to systematically review the literature regarding the effects of MgS on muscle soreness in physically active individuals. We focused exclusively on MgS, excluding those studies in which magnesium was administered together with other substances.
METHODS
METHODS
Three electronic databases and literature sources (PUBMED, SCOPUS and Web of Sciences-Core Collection) were searched, in accordance with PRISMA guidelines. After the database search, 1254 articles were identified, and after excluding duplicates, 960 articles remained. Among these, 955 were excluded following the title and abstract screening. The remaining 5 articles were screened in full text and 4 study met the eligibility criteria.
RESULTS
RESULTS
These studies showed that MgS reduced muscle soreness, improved performance, recovery and induced a protective effect on muscle damage.
CONCLUSION
CONCLUSIONS
To reach these positive effects, individuals engaged in intense exercise should have a Mg requirement 10-20% higher than sedentary people, to be taken in capsules and 2 h before training. Moreover, it is suggested to maintain magnesium levels in the recommended range during the off-season.
SYSTEMATIC REVIEW REGISTRATION
BACKGROUND
PROSPERO registration number: CRD42024501822.
Identifiants
pubmed: 38970118
doi: 10.1186/s12967-024-05434-x
pii: 10.1186/s12967-024-05434-x
doi:
Substances chimiques
Magnesium
I38ZP9992A
Types de publication
Systematic Review
Journal Article
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
629Subventions
Organisme : Italian Ministry of Education and University
ID : 2017FJSM9S
Informations de copyright
© 2024. The Author(s).
Références
Volpe SL. Magnesium and the Athlete. Cur Sports Med Rep. 2015. https://doi.org/10.1249/JSR.0000000000000178 .
doi: 10.1249/JSR.0000000000000178
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J. 2012;5(Suppl 1):i3–14.
doi: 10.1093/ndtplus/sfr163
pubmed: 26069819
pmcid: 4455825
De Baaij JH, Hoenderop JG, Bindels RJ. Regulation of magnesium balance: lessons learned from human genetic disease. Clin Kidney J. 2012;5(Suppl 1):i15–24. https://doi.org/10.1093/ndtplus/sfr164 .
doi: 10.1093/ndtplus/sfr164
pubmed: 26069817
pmcid: 4455826
Uwitonze AM, Razzaque MS. Role of magnesium in vitamin d activation and function. J Am Osteopath Assoc. 2018;118(3):181–9.
doi: 10.7556/jaoa.2018.037
pubmed: 29480918
Deuster PA, Dolev E, Kyle SB, Anderson RA, Schoomaker EB. Magnesium homeostasis during high-intensity anaerobic exercise in men. J Appl Physiol. 1987;62(2):545–50. https://doi.org/10.1152/jappl.1987.62.2.545 .
doi: 10.1152/jappl.1987.62.2.545
pubmed: 3558215
Lares MJ, Monteiro C. Exercise and magnesium. In: Nishisawa Y, Morii H, Durlach J, editors. New perspectives inmagnesium research: nutrition and health. Osaka: Springer Science; 2006.
Felig P, Cherif A, Minagawa A, Wahren J. Hypoglycemia during prolonged exercise in normal men. N Engl J Med. 1982;306:895–900.
doi: 10.1056/NEJM198204153061503
pubmed: 7038492
Mooren FC, Golf SW, Lechtermann A, Volker K. Alterazioni del Mg2+ ionizzato nel sangue umano dopo l’esercizio. Vita Sci. 2005;77:1211–25.
Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World J Dia. 2015;6:1152–7.
doi: 10.4239/wjd.v6.i10.1152
Zhang Y, Xun P, Wang R, Mao L, He K. Can magnesium enhance exercise performance? Nutrients. 2017;9(9):946. https://doi.org/10.3390/nu9090946 .
doi: 10.3390/nu9090946
pubmed: 28846654
pmcid: 5622706
Wang L, Dong Y, Yu X, Shangguan DH, Zhao R, et al. Analysis of glucose and lactate in dialysate from hypothalamus of rats after exhausting swimming using microdialysis. Biomed Chromatogr. 2002;16(7):427–31. https://doi.org/10.1002/bmc.177 .
doi: 10.1002/bmc.177
pubmed: 12378551
Fedewa MV, Spencer SO, Williams TD, Becker ZE, Fuqua CA. Effect of branched-chain amino acid supplementation on muscle soreness following exercise: a meta-analysis. Int J Vitam Nutr Res. 2019;89(5–6):348–56. https://doi.org/10.1024/0300-9831/a000543 .
doi: 10.1024/0300-9831/a000543
pubmed: 30938579
Heiss R, Lutter C, Freiwald J, Hoppe MW, Grim C, et al. Advances in delayed-onset muscle soreness (doms)—part ii: treatment and prevention. Sportverletz Sportschaden. 2019;33(1):21–9. https://doi.org/10.1055/a-0810-3516 .
doi: 10.1055/a-0810-3516
pubmed: 30865998
Chen HY, Cheng FC, Pan HC, Hsu JC, Wang MF. Magnesium enhances exercise performance via increasing glucose availability in the blood, muscle, and brain during exercise. PLoS ONE. 2014;9: e85486.
doi: 10.1371/journal.pone.0085486
pubmed: 24465574
pmcid: 3896381
Cheng SM, Yang LL, Chen SH, Hsu MH, Chen IJ, et al. Magnesium sulfate enhances exercise performance and manipulates dynamic changes in peripheral glucose utilization. Eur J Appl Physiol. 2010;108:363–9.
doi: 10.1007/s00421-009-1235-y
pubmed: 19816708
Garrison SR, Allan GM, Sekhon RK, Musini VM, Khan KM. Magnesium for skeletal muscle cramps. Cochrane Database Systematic Rev. 2012. https://doi.org/10.1002/14651858.CD009402.pub2 .
doi: 10.1002/14651858.CD009402.pub2
Maria José L, Cristina Paula M, Catarina Nunes M, Diana Aguiar S, Analiza Monica S, et al. Magnesium status and exercise performance in athletes. Trace Elements Electroiytes. 2014;31(1):13–20.
Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi MM. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2021;61(17):2921–37. https://doi.org/10.1080/10408398.2020.1790498 .
doi: 10.1080/10408398.2020.1790498
pubmed: 32654500
Asbaghi O, Moradi S, Nezamoleslami S, Moosavian SP, Hojjati Kermani MA, et al. The effects of magnesium supplementation on lipid profile among type 2 diabetes patients: a systematic review and meta-analysis of randomized controlled trials. Biol Trace Elem Res. 2021;199(3):861–73. https://doi.org/10.1007/s12011-020-02209-5 .
doi: 10.1007/s12011-020-02209-5
pubmed: 32468224
Marshall NS, Serinel Y, Killick R, Child JM, Raisin I, et al. Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: a systematic review. Sleep Med Rev. 2019;48: 101218. https://doi.org/10.1016/j.smrv.2019.101218 .
doi: 10.1016/j.smrv.2019.101218
pubmed: 31678660
Asbaghi NS, Serinel Y, Killick R, Child JM, Raisin I, et al. Magnesium supplementation for the treatment of restless legs syndrome and periodic limb movement disorder: a systematic review. Sleep Med Rev. 2019;48: 101218. https://doi.org/10.1016/j.smrv.2019.101218 .
doi: 10.1016/j.smrv.2019.101218
Reyngoudt H, Lopez Kolkovsky AL, Carlier PG. Free intramuscular Mg2+ concentration calculated using both 31 P and 1 H NMRS-based pH in the skeletal muscle of Duchenne muscular dystrophy patients. NMR Biomed. 2019. https://doi.org/10.1002/nbm.4115 .
doi: 10.1002/nbm.4115
pubmed: 31184793
Aagaard NK, Andersen H, Vilstrup H, Clausen T, Jakobsen J, et al. Magnesium supplementation and muscle function in patients with alcoholic liver disease: a randomized, placebo-controlled trial. Scand J Gastroenterol. 2005;40:972–9.
doi: 10.1080/00365520510012361
pubmed: 16173138
Weller E, Bachert P, Meinck HM, Friedmann B, Bartsch P, et al. Lack of effect of oral Mgsupplementation on Mg in serum, blood cells and calf muscle. Med Sci Sports Exerc. 1998;30:1584–91.
doi: 10.1097/00005768-199811000-00005
pubmed: 9813870
Setaro L, Santos-Silva PR, Nakano EY, et al. Magnesium status and the physical performance of volleyball players: effects of magnesium supplementation. J Sports Sci. 2014;32:438–45.
doi: 10.1080/02640414.2013.828847
pubmed: 24015935
Finstad EW, Newhouse IJ, Lukaski HC, McAuliffe JE, Stewart CR. The effects of magnesium supplementation on exercise performance. Med Sci Sports Exerc. 2001;33:493–8.
doi: 10.1097/00005768-200103000-00024
pubmed: 11252079
Brilla LR, Haley TF. Effect of magnesium supplementation on strength training in humans. J Am Coll Nutr. 1992;11:326–9.
doi: 10.1080/07315724.1992.10718233
pubmed: 1619184
Peveler WW, Palmer TG. Effect of magnesium lactate dihydrate and calcium lactate monohydrate on 20-km cycling time trial performance. J Strength Cond Res. 2012;26(4):1149–53. https://doi.org/10.1519/JSC.0b013e31822dcd7f .
doi: 10.1519/JSC.0b013e31822dcd7f
pubmed: 22398820
Kass LS, Poeira F. The effect of acute vs chronic magnesium supplementation on exercise and recovery on resistance exercise, blood pressure and total peripheral resistance on normotensive adults. J Intl Soc Sports Nutr. 2015;12:19.
doi: 10.1186/s12970-015-0081-z
Gulick DT, Agarwal M, Josephs J, Reinmiller A, Zimmerman B. Effects of MagPro on muscle performance. J Strength Cond Res. 2012;26:2478–83.
doi: 10.1519/JSC.0b013e31823f2863
pubmed: 22067254
Chycki J, Golas A, Halz M, Maszczyk A, Toborek M, et al. Chronic ingestion of sodium and potassium bicarbonate, with potassium, magnesium and calcium citrate improves anaerobic performance in elite soccer players. Nutrients. 2018;10(11):1610. https://doi.org/10.3390/nu10111610 .
doi: 10.3390/nu10111610
pubmed: 30388775
pmcid: 6266022
Gonzalez AM, Pinzone AG, Bram J, Salisbury JL, Lee S, et al. Effect of multi-ingredient preworkout supplementation on repeated sprint performance in recreationally active men and women. J Strength Cond Res. 2020;34(4):918–23. https://doi.org/10.1519/JSC.0000000000003480 .
doi: 10.1519/JSC.0000000000003480
pubmed: 31913254
Czaja J, Lebiedzińska A, Marszałł M, Szefer P. Evaluation for magnesium and vitamin B6 supplementation among polish elite athletes. Rocz Panstw Zakl Hig. 2011;62(4):413–8.
pubmed: 22435297
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;29(372): n71. https://doi.org/10.1136/bmj.n71 .
doi: 10.1136/bmj.n71
Reno AM, Green M, Killen LG, O’Neal EK, Pritchett K, et al. Effects of magnesium supplementation on muscle soreness and performance. J Strength Cond Res. 2022;36(8):2198–203. https://doi.org/10.1519/JSC.0000000000003827 .
doi: 10.1519/JSC.0000000000003827
pubmed: 33009349
Steward CJ, Zhou Y, Keane G, Cook MD, Liu Y, et al. One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running. Eur J Appl Physiol. 2019;119(11–12):2617–27. https://doi.org/10.1007/s00421-019-04238-y .
doi: 10.1007/s00421-019-04238-y
pubmed: 31624951
Cordova Martínez A, Fernández-Lázaro D, Mielgo-Ayuso J, Seco Calvo J, Caballero GA. Effect of magnesium supplementation on muscular damage markers in basketball players during a full season. Magnes Res. 2017;30(2):61–70. https://doi.org/10.1684/mrh.2017.0424 .
doi: 10.1684/mrh.2017.0424
pubmed: 28816171
Cordova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of magnesium supplementation in muscle damage of professional cyclists competing in a stage race. Nutrients. 2019;11(8):1927. https://doi.org/10.3390/nu11081927 .
doi: 10.3390/nu11081927
pubmed: 31426321
pmcid: 6723322
Costello R, Wallace TC, Rosanoff A. Magnesium. Adv Nutr. 2016;7(1):199–201. https://doi.org/10.3945/an.115.008524.
doi: 10.3945/an.115.008524.
pubmed: 26773023
pmcid: 4717872
Haralambie G, Senser L. Metabolic changes in man during long-distance swimming. Eur J Appl Physiol Occup Physiol. 1980;43(2):115–25. https://doi.org/10.1007/BF00422442 .
doi: 10.1007/BF00422442
pubmed: 7389711
Santos DA, Matias CN, Monteiro CP, Silva AM, Rocha PM, et al. Magnesium intake is associated with strength performance inelite basketball, handball and volleyball players. Magnes Res. 2011;24:215–9.
doi: 10.1684/mrh.2011.0290
pubmed: 21983266
Lamb GD, Stephenson DG. Effect of Mg2+ on the control of Ca2+ release in skeletal muscle fibers of the toad. J Physiol. 1994;434:507–28.
doi: 10.1113/jphysiol.1991.sp018483
Nielsen FH, Lukaski HC. Update on the relationship between magnesium and exercise. Magnes Res. 2006;19(3):180–9.
pubmed: 17172008
Veronese N, Berton L, Carraro S, Bolzetta F, De Rui M, et al. Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial. Am J Clin Nutr. 2014;100:974–81.
doi: 10.3945/ajcn.113.080168
pubmed: 25008857
Newhouse IJ, Finstad EW. The effects of magnesium supplementation on exercise performance. Clin J Sport Med. 2000;10:195–200.
doi: 10.1097/00042752-200007000-00008
pubmed: 10959930
Muneyvirci-Delale O, Nacharaju V, Altura B, Altura B. Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women. Fertil Steril. 1998;69(5):958–62.
doi: 10.1016/S0015-0282(98)00053-3
pubmed: 9591508
Peters EN, Yardley H, Harrison A, Eglit GML, Antonio J, Turcotte C, Bonn-Miller MO. A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD) and cannabigerol (CBG) based beverage powder to support recovery from delayed onset muscle soreness (DOMS). J Int Soc Sports Nutr. 2023. https://doi.org/10.1080/15502783.2023.2280113 .
doi: 10.1080/15502783.2023.2280113
pubmed: 37947792
pmcid: 10653658
Kissow J, Jacobsen KJ, Gunnarsson TP, Jessen S, Hostrup M. Effects of follicular and luteal phase-based menstrual cycle resistance training on muscle strength and mass. Sports Med. 2022;52(12):2813–9. https://doi.org/10.1007/s40279-022-01679-y .
doi: 10.1007/s40279-022-01679-y
pubmed: 35471634
Samulowitz A, Gremyr I, Eriksson E, Hensing G. “Brave men” and “emotional women”: a theory-guided literature review on gender bias in health care and gendered norms towards patients with chronic pain. Pain Res Manag. 2018;25(2018):6358624. https://doi.org/10.1155/2018/6358624 .
doi: 10.1155/2018/6358624
Wang R, Chen C, Liu W, Zhou T, Xun P, et al. The effect of magnesium supplementation on muscle fitness: a meta-analysis and systematic review. Magnes Res. 2017;30(4):120–32. https://doi.org/10.1684/mrh.2018.0430 .
doi: 10.1684/mrh.2018.0430
pubmed: 29637897
Ates M, Kizildag S, Yuksel O, et al. Dose-dependent absorption profile of different magnesium compounds. Biol Trace Elem Res. 2019;192:244–51. https://doi.org/10.1007/s12011-019-01663-0) .
doi: 10.1007/s12011-019-01663-0)
pubmed: 30761462
https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/#h2 .
Dullo P, Vedi N. Changes in serum calcium, magnesium and inorganic phosphorus levels during different phases of the menstrual cycle. J Hum Reprod Sci. 2008;1(2):77–80. https://doi.org/10.4103/0974-1208.44115 .
doi: 10.4103/0974-1208.44115
pubmed: 19562050
pmcid: 2700668
Schuchardt JP, Hahn A. Intestinal absorption and factors influencing bioavailability of magnesium-an update. Curr Nutr Food Sci. 2017;13(4):260–78. https://doi.org/10.2174/1573401313666170427162740 .
doi: 10.2174/1573401313666170427162740
pubmed: 29123461
pmcid: 5652077
Peters EN, Yardley H, Harrison A, Eglit GML, Antonio J, Turcotte C, Bonn-Miller MO. A randomized, double-blind, placebo-controlled, repeated-dose pilot study of the safety, tolerability, and preliminary effects of a cannabidiol (CBD)- and cannabigerol (CBG)-based beverage powder to support recovery from delayed onset muscle soreness (DOMS). J Int Soc Sports Nutr. 2023. https://doi.org/10.1080/15502783.2023.2280113 .
doi: 10.1080/15502783.2023.2280113
pubmed: 37947792
pmcid: 10653658