Macro and micro structural preservation of grey matter integrity after 24 weeks of rTMS in Alzheimer's disease patients: a pilot study.
Alzheimer’s disease
Brain plasticity
Cortex
Default mode network
Microstructural
Precuneus
Transcranial magnetic stimulation
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
05 Jul 2024
05 Jul 2024
Historique:
received:
18
01
2024
accepted:
12
06
2024
medline:
6
7
2024
pubmed:
6
7
2024
entrez:
5
7
2024
Statut:
epublish
Résumé
Alzheimer's Disease (AD) is characterized by structural and functional dysfunction involving the Default Mode Network (DMN), for which the Precuneus (PC) is a key node. We proposed a randomized double-blind pilot study to determine neurobiological changes after 24 weeks of PC-rTMS in patients with mild-to-moderate AD. Sixteen patients were randomly assigned to SHAM or PC-rTMS, and received an intensive 2-weeks course with daily rTMS sessions, followed by a maintenance phase in which rTMS has been applied once a week. Before and after the treatment structural and functional MRIs were collected. Our results showed macro- and micro-structural preservation in PC-rTMS compared to SHAM-rTMS group after 24 weeks of treatment, correlated to an increase of functional connectivity (FC) within the PC in the PC-rTMS group. Even if preliminary, these results trigger the possibility of using PC-rTMS to arrest atrophy progression by manipulating distributed network connectivity patterns.
Identifiants
pubmed: 38970141
doi: 10.1186/s13195-024-01501-z
pii: 10.1186/s13195-024-01501-z
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
152Subventions
Organisme : BrightFocus Foundation
ID : A2019523S
Organisme : Ministero della Salute
ID : Ricerca corrente 2018
Informations de copyright
© 2024. The Author(s).
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