A 10-Year Longitudinal Study of Brain Cortical Thickness in People with First-Episode Psychosis Using Normative Models.

cortical thickness long-term follow up normative modeling schizophrenia

Journal

Schizophrenia bulletin
ISSN: 1745-1701
Titre abrégé: Schizophr Bull
Pays: United States
ID NLM: 0236760

Informations de publication

Date de publication:
05 Jul 2024
Historique:
medline: 6 7 2024
pubmed: 6 7 2024
entrez: 6 7 2024
Statut: aheadofprint

Résumé

Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year longitudinal study, we aimed to characterize the temporal evolution of cortical correlates of psychosis and their associations with symptoms. Structural magnetic resonance imaging (MRI) from people with first-episode psychosis and controls (n = 79 and 218) were obtained at enrollment, after 12 months (n = 67 and 197), and 10 years (n = 23 and 77), within the Thematically Organized Psychosis (TOP) study. Normative models for cortical thickness estimated on public MRI datasets (n = 42 983) were applied to TOP data to obtain deviation scores for each region and timepoint. Positive and Negative Syndrome Scale (PANSS) scores were acquired at each timepoint along with registry data. Linear mixed effects models assessed effects of diagnosis, time, and their interactions on cortical deviations plus associations with symptoms. LMEs revealed conditional main effects of diagnosis and time × diagnosis interactions in a distributed cortical network, where negative deviations in patients attenuate over time. In patients, symptoms also attenuate over time. LMEs revealed effects of anterior cingulate on PANSS total, and insular and orbitofrontal regions on PANSS negative scores. This long-term longitudinal study revealed a distributed pattern of cortical differences which attenuated over time together with a reduction in symptoms. These findings are not in line with a simple neurodegenerative account of schizophrenia, and deviations from normative models offer a promising avenue to develop biomarkers to track clinical trajectories over time.

Sections du résumé

BACKGROUND BACKGROUND
Clinical forecasting models have potential to optimize treatment and improve outcomes in psychosis, but predicting long-term outcomes is challenging and long-term follow-up data are scarce. In this 10-year longitudinal study, we aimed to characterize the temporal evolution of cortical correlates of psychosis and their associations with symptoms.
DESIGN METHODS
Structural magnetic resonance imaging (MRI) from people with first-episode psychosis and controls (n = 79 and 218) were obtained at enrollment, after 12 months (n = 67 and 197), and 10 years (n = 23 and 77), within the Thematically Organized Psychosis (TOP) study. Normative models for cortical thickness estimated on public MRI datasets (n = 42 983) were applied to TOP data to obtain deviation scores for each region and timepoint. Positive and Negative Syndrome Scale (PANSS) scores were acquired at each timepoint along with registry data. Linear mixed effects models assessed effects of diagnosis, time, and their interactions on cortical deviations plus associations with symptoms.
RESULTS RESULTS
LMEs revealed conditional main effects of diagnosis and time × diagnosis interactions in a distributed cortical network, where negative deviations in patients attenuate over time. In patients, symptoms also attenuate over time. LMEs revealed effects of anterior cingulate on PANSS total, and insular and orbitofrontal regions on PANSS negative scores.
CONCLUSIONS CONCLUSIONS
This long-term longitudinal study revealed a distributed pattern of cortical differences which attenuated over time together with a reduction in symptoms. These findings are not in line with a simple neurodegenerative account of schizophrenia, and deviations from normative models offer a promising avenue to develop biomarkers to track clinical trajectories over time.

Identifiants

DOI: 10.1093/schbul/sbae107 PMID: 38970378
pubmed: 38970378
pii: 7708454
doi: 10.1093/schbul/sbae107
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Research Council of Norway
ID : 223273
Organisme : KG Jebsen Stiftelsen
Organisme : European Research Council
Pays : International
Organisme : South-Eastern Norway Regional Health Authority
ID : 2006233

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

Auteurs

Pierre Berthet (P)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Beathe C Haatveit (BC)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Rikka Kjelkenes (R)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Amanda Worker (A)

Department of Psychosis Studies, Institute of Psychiatry, King's College, London, UK.

Seyed Mostafa Kia (SM)

Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands.
Department of Psychiatry, Utrecht University Medical Center, Utrecht, the Netherlands.
Department Cognitive Science and Artificial Intelligence, Tilburg University, the Netherlands.

Thomas Wolfers (T)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.
ORCID: 0000-0002-7693-0621

Saige Rutherford (S)

Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands.
Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.

Dag Alnaes (D)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-7361-5418

Richard Dinga (R)

Department Cognitive Science and Artificial Intelligence, Tilburg University, the Netherlands.

Mads L Pedersen (ML)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Andreas Dahl (A)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Sara Fernandez-Cabello (S)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Paola Dazzan (P)

Department of Psychosis Studies, Institute of Psychiatry, King's College, London, UK.

Ingrid Agartz (I)

Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Ragnar Nesvåg (R)

Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.

Torill Ueland (T)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Ole A Andreassen (OA)

Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Carmen Simonsen (C)

Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.

Lars T Westlye (LT)

Department of Psychology, University of Oslo, Oslo, Norway.
Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-8644-956X

Ingrid Melle (I)

Norwegian Center for Mental Disorders Research (NORMENT), University of Oslo, and Oslo University Hospital, Oslo, Norway.

Andre Marquand (A)

Donders Institute for Brain, Cognition, and Behaviour, Radboud University, Nijmegen, the Netherlands.
Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.

Classifications MeSH