Hydroxyurea in sickle cell disease and invasive bacterial infections: a case-control study.

early treatment hydroxyurea invasive bacterial infections sickle cell disease spleen function

Journal

Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049

Informations de publication

Date de publication:
06 Jul 2024
Historique:
received: 23 01 2024
medline: 6 7 2024
pubmed: 6 7 2024
entrez: 6 7 2024
Statut: aheadofprint

Résumé

Hydroxyurea decreases painful events among children with sickle cell disease but could increase the risk of infections in treated patients through leucopenia. We performed a case-control study, comparing hydroxyurea treatment for sickle cell disease in cases with an invasive bacterial infection and in controls without infection. No difference was found.

Identifiants

pubmed: 38970408
pii: 7708534
doi: 10.1093/jpids/piae071
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

Auteurs

Alice Pascault (A)

Assistance Publique Hôpitaux De Paris, Paris, France.

Bérengère Koehl (B)

Assistance Publique Hôpitaux De Paris, Paris, France.
Department of Child Haematology, Reference Center for Sickle Cell Disease, Robert-Debré University Hospital, Paris, France.
Laboratory of Excellence (Labex GR-Ex), Paris, France.

Valentine Brousse (V)

Assistance Publique Hôpitaux De Paris, Paris, France.
Department of Child Haematology, Reference Center for Sickle Cell Disease, Robert-Debré University Hospital, Paris, France.
Laboratory of Excellence (Labex GR-Ex), Paris, France.

Malika Benkerrou (M)

Assistance Publique Hôpitaux De Paris, Paris, France.
Department of Child Haematology, Reference Center for Sickle Cell Disease, Robert-Debré University Hospital, Paris, France.

Jean Gaschignard (J)

Department of Paediatrics, Groupe Hospitalier Nord Essonne, Longjumeau, France.
INSERM U1137 Infection, Antimicrobiens, Modélisation, Evolution, Paris, France.

Classifications MeSH