Insights in caveolae protein structure arrangements and their local lipid environment.

caveolae caveolar coat caveolin1 cavin lipid composition plasma membrane

Journal

Biological chemistry

ISSN: 1437-4315

Titre abrégé: Biol Chem

Pays: Germany

ID NLM: 9700112

Informations de publication

Date de publication:
08 Jul 2024

Historique:

received: 19 03 2024

accepted: 19 06 2024

medline: 6 7 2024

pubmed: 6 7 2024

entrez: 6 7 2024

Statut: aheadofprint

Résumé

Caveolae are 50-80 nm sized plasma membrane invaginations found in adipocytes, endothelial cells or fibroblasts. They are involved in endocytosis, lipid uptake and the regulation of the cellular lipid metabolism as well as sensing and adapting to changes in plasma membrane tension. Caveolae are characterized by their unique lipid composition and their specific protein coat consisting of caveolin and cavin proteins. Recently, detailed structural information was obtained for the major caveolae protein caveolin1 showing the formation of a disc-like 11-mer protein complex. Furthermore, the importance of the cavin disordered regions in the generation of cavin trimers and caveolae at the plasma membrane were revealed. Thus, finally, structural insights about the assembly of the caveolar coat can be elucidated. Here, we review recent developments in caveolae structural biology with regard to caveolae coat formation and caveolae curvature generation. Secondly, we discuss the importance of specific lipid species necessary for caveolae curvature and formation. In the last years, it was shown that specifically sphingolipids, cholesterol and fatty acids can accumulate in caveolae invaginations and may drive caveolae endocytosis. Throughout, we summarize recent studies in the field and highlight future research directions.

Identifiants

DOI: 10.1515/hsz-2024-0046 PMID: 38970809

pubmed: 38970809

pii: hsz-2024-0046

doi: 10.1515/hsz-2024-0046

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Informations de copyright

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