Melatonin improves fertilization rate in assisted reproduction: Systematic review and meta-analysis.

Assisted reproduction outcomes Human reproduction In vitro fertilization Melatonin Ovarian hyperstimulation syndrome Sytematic review

Journal

Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734

Informations de publication

Date de publication:
05 Jul 2024
Historique:
received: 23 01 2024
revised: 01 04 2024
accepted: 13 05 2024
medline: 7 7 2024
pubmed: 7 7 2024
entrez: 6 7 2024
Statut: aheadofprint

Résumé

Melatonin is a hormone produced by the pineal gland and it has antioxidant properties. This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis. Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes. The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001). Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.

Sections du résumé

BACKGROUND BACKGROUND
Melatonin is a hormone produced by the pineal gland and it has antioxidant properties.
AIM OBJECTIVE
This study aimed to evaluate the effects of melatonin on assisted reproductive technologies through a systematic review and a meta-analysis.
MATERIALS AND METHODS METHODS
Search strategies were used in PubMed and in other databases covering the last 15 years. After screening for eligibility, 17 articles were selected for the systematic review. For the meta-analysis statistics, two groups were formed, the treatment group (with melatonin) and the control group (without melatonin) for various assisted reproduction outcomes.
RESULTS RESULTS
The main results were that no statistical differences were found concerning the clinical pregnancy outcome (p = 0.64), but there was a statistical difference with respect to Mature Oocytes (MII) (p = 0.001), antral follicle count (p = 0.0002), and the fertilization rate (p ≤ 0.0001).
CONCLUSIONS CONCLUSIONS
Melatonin had beneficial effects such as the improvement in the fertilization rate, although the authors did not obtain significance in the clinical pregnancy rate.

Identifiants

DOI: 10.1016/j.clinsp.2024.100397 PMID: 38971124
pubmed: 38971124
pii: S1807-5932(24)00074-7
doi: 10.1016/j.clinsp.2024.100397
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100397

Informations de copyright

Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflicts of interest.

Auteurs

Eduardo Carvalho de Arruda Veiga (ECA)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil; Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), São Paulo, SP, Brazil. Electronic address: eduardo.veiga@fm.usp.br.

Marise Samama (M)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil; Department of Gynecology, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.

Fabio Ikeda (F)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil.

Giovanna Santos Cavalcanti (GS)

Lim-58 - Laboratório de Ginecologia Estrutural e Molecular da Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.

Amanda Sartor (A)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil; Department of Gynecology, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil.

Suelen Fernanda Parames (SF)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil.

Edmund C Baracat (EC)

Lim-58 - Laboratório de Ginecologia Estrutural e Molecular da Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.

Joji Ueno (J)

GERA Instituto de Ensino e Pesquisa em Medicina Reprodutiva de, São Paulo, SP, Brazil.

Jose Maria Soares Junior (JMS)

Lim-58 - Laboratório de Ginecologia Estrutural e Molecular da Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), São Paulo, SP, Brazil.

Classifications MeSH