Coffee, PI3K signaling pathway, and prostate cancer: a prospective study in the Health Professionals Follow-up Study.

coffee cohort studies nutrition prostate cancer tumor markers

Journal

Journal of the Academy of Nutrition and Dietetics
ISSN: 2212-2672
Titre abrégé: J Acad Nutr Diet
Pays: United States
ID NLM: 101573920

Informations de publication

Date de publication:
04 Jul 2024
Historique:
received: 16 02 2023
revised: 22 05 2024
accepted: 01 07 2024
medline: 7 7 2024
pubmed: 7 7 2024
entrez: 6 7 2024
Statut: aheadofprint

Résumé

Higher coffee intake has been associated with reduced risk of prostate cancer, particularly aggressive forms. The activation of the PI3K signaling pathway plays an important role in prostate carcinogenesis. To evaluate associations between pre-diagnostic coffee intake and a PI3K activation score, the expression/presence of PI3K regulators, and downstream effectors in tumor tissue from men with prostate cancer in the Health Professionals Follow-up Study, a prospective cohort study conducted in the US. A case-only study design was applied. Coffee intake was assessed using validated food frequency questionnaires completed in 1986 and every four years thereafter until prostate cancer diagnosis. Study participants comprised 1,242 men diagnosed with prostate cancer from 1986 to 2009 and with tumor markers assessed from tissue microarrays constructed from tumor specimens. The outcomes include the PI3K activation score; expression of insulin receptor and IGF1 receptor; angiogenesis markers; and presence of the tumor suppressor PTEN, chronic and acute inflammation, simple atrophy, and post-atrophic hyperplasia. Multivariable linear or logistic regression was conducted to estimate associations between coffee intake and tumor marker expression/presence. Among coffee drinkers (86.6% of the population), median (25 Coffee intake was not observed to be associated with PI3K activation, related regulators, and several effectors in prostate tumor tissue. Studies exploring alternative pathways or earlier steps in carcinogenesis are needed to investigate the underlying mechanisms of the coffee and prostate cancer association.

Sections du résumé

BACKGROUND BACKGROUND
Higher coffee intake has been associated with reduced risk of prostate cancer, particularly aggressive forms. The activation of the PI3K signaling pathway plays an important role in prostate carcinogenesis.
OBJECTIVE OBJECTIVE
To evaluate associations between pre-diagnostic coffee intake and a PI3K activation score, the expression/presence of PI3K regulators, and downstream effectors in tumor tissue from men with prostate cancer in the Health Professionals Follow-up Study, a prospective cohort study conducted in the US.
DESIGN METHODS
A case-only study design was applied. Coffee intake was assessed using validated food frequency questionnaires completed in 1986 and every four years thereafter until prostate cancer diagnosis.
PARTICIPANTS/SETTING METHODS
Study participants comprised 1,242 men diagnosed with prostate cancer from 1986 to 2009 and with tumor markers assessed from tissue microarrays constructed from tumor specimens.
MAIN OUTCOME MEASURES METHODS
The outcomes include the PI3K activation score; expression of insulin receptor and IGF1 receptor; angiogenesis markers; and presence of the tumor suppressor PTEN, chronic and acute inflammation, simple atrophy, and post-atrophic hyperplasia.
STATISTICAL ANALYSES PERFORMED METHODS
Multivariable linear or logistic regression was conducted to estimate associations between coffee intake and tumor marker expression/presence.
RESULTS RESULTS
Among coffee drinkers (86.6% of the population), median (25
CONCLUSIONS CONCLUSIONS
Coffee intake was not observed to be associated with PI3K activation, related regulators, and several effectors in prostate tumor tissue. Studies exploring alternative pathways or earlier steps in carcinogenesis are needed to investigate the underlying mechanisms of the coffee and prostate cancer association.

Identifiants

DOI: 10.1016/j.jand.2024.07.001 PMID: 38971221
pubmed: 38971221
pii: S2212-2672(24)00537-9
doi: 10.1016/j.jand.2024.07.001
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Rui Song (R)

Doctoral student, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Konrad H Stopsack (KH)

Assistant Professor, Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Assistant Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Junkun Ren (J)

Masters student, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Lorelei A Mucci (LA)

Professor, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Steven K Clinton (SK)

Professor, Division of Medical Oncology, Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH, USA; Director, Genitourinary Oncology, The Arthur G. James Cancer Hospital, The Ohio State University, Columbus, OH, USA; Program Leader, Molecular Carcinogenesis and Chemoprevention, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Massimo Loda (M)

Professor and Chair, Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Professor of Pathology, Emeritus, Harvard Medical Schoool, Dana-Farber Cancer Institute, Boston, MA.

Molin Wang (M)

Associate Professor, Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Associate Professor, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Edward L Giovannucci (EL)

Professor, Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Kathryn M Wilson (KM)

Senior Research Scientist, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Stephanie A Smith-Warner (SA)

Senior Lecturer, Departments of Nutrition and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: swarner@hsph.harvard.edu.

Classifications MeSH