In vitro biotransformation of 3-methylmethcathinone (3-MMC) through incubation with human liver microsomes and cytosol and application to in vivo samples.

3-methylmethcathinone (3-MMC) Human liver cytosol (HLCYT) Human liver microsomes (HLM) In vitro metabolisation In vivo metabolisation Metaphedrone

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
03 Jul 2024
Historique:
received: 31 05 2024
revised: 01 07 2024
accepted: 02 07 2024
medline: 8 7 2024
pubmed: 8 7 2024
entrez: 7 7 2024
Statut: aheadofprint

Résumé

Synthetic cathinones are the second largest group of new psychoactive substances (NPS) monitored by the European Monitoring Centre for Drugs and Drug Addiction. Although 3-methylmethcathinone (3-MMC, C

Identifiants

DOI: 10.1016/j.jpba.2024.116335 PMID: 38972226
pubmed: 38972226
pii: S0731-7085(24)00375-3
doi: 10.1016/j.jpba.2024.116335
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

116335

Informations de copyright

Copyright © 2024 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Natan Van Wichelen (N)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address: natan.vanwichelen@uantwerpen.be.

Andrea Estévez-Danta (A)

Aquatic One Health Research Center (ARCUS) & Department of Analytical Chemistry, Nutrition and Food Chemistry, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, IIAA building, Santiago de Compostela 15782, Spain.

Lidia Belova (L)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Fatima den Ouden (F)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Nick Verougstraete (N)

Department of Laboratory Medicine, Ghent University Hospital, Ghent 9000, Belgium.

Maarten Roggeman (M)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Tim Boogaerts (T)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Maarten Quireyns (M)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Rani Robeyns (R)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Nik De Brabanter (N)

Laboratory Medicine, AZ Delta General Hospital, Roeselare 8800, Belgium.

José Benito Quintana (JB)

Aquatic One Health Research Center (ARCUS) & Department of Analytical Chemistry, Nutrition and Food Chemistry, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, IIAA building, Santiago de Compostela 15782, Spain.

Rosario Rodil (R)

Aquatic One Health Research Center (ARCUS) & Department of Analytical Chemistry, Nutrition and Food Chemistry, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, IIAA building, Santiago de Compostela 15782, Spain.

Alexander L N van Nuijs (ALN)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Adrian Covaci (A)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium.

Celine Gys (C)

Toxicological Centre, University of Antwerp, Antwerp 2610, Belgium; Exposome Center of Excellence, University of Antwerp, Universiteitsplein 1, Antwerp 2610, Belgium. Electronic address: celine.gys@uantwerpen.be.

Classifications MeSH