Structurally diverse diterpenoids from the leaves of Croton mangelong and their anti-diabetic activity.
Croton mangelong
Euphorbiaceae
anti-hyperglycemic and anti-diabetic activities
neo-clerodane diterpenes
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
05 Jul 2024
05 Jul 2024
Historique:
received:
01
04
2024
revised:
02
07
2024
accepted:
04
07
2024
medline:
8
7
2024
pubmed:
8
7
2024
entrez:
7
7
2024
Statut:
aheadofprint
Résumé
Eighteen compounds including eleven previously undescribed diterpenes were isolated from the leaves of Croton mangelong. The structures were determined by HRESIMS, IR, NMR, X-ray diffraction and ECD spectroscopic analysis. All isolates were assayed for their anti-hyperglycemic activities in insulin resistance (IR) 3T3-L1 adipocytes, and compound 4 was tested for its anti-diabetic activity in vivo. Results suggested compound 4 could effectively reduce blood glucose level in diabetic SD rats in a dose of 30 mg/kg.
Identifiants
pubmed: 38972440
pii: S0031-9422(24)00243-7
doi: 10.1016/j.phytochem.2024.114206
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114206Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work in this paper.