Impact of maternal

Maternal synbiotic supplementation during pregnancy and lactation can significantly influence the immune system. Prebiotics and probiotics have a positive impact on the immune system by preventing or ameliorating among others intestinal disorders. This study focused on the immunomodulatory effects of Lewis rats were orally administered with the synbiotic or vehicle during pregnancy (21 days) and lactation (21 days). At the weaning day, small intestine (SI), mammary gland (MG), adipose tissue, milk, mesenteric lymph nodes (MLN), salivary gland (SG), feces and cecal content were collected from the mothers. The immunoglobulinome profile showed increased IgG2c in plasma and milk, as well as elevated sIgA in feces at weaning. The supplementation improved lipid metabolism through enhanced brown adipose tissue activity and reinforced the intestinal barrier by increasing the expression of These findings indicate that maternal synbiotic supplementation during gestation and lactation improves their immunological status and improved milk composition.

Informations de copyright

Copyright © 2024 Sáez-Fuertes, Kapravelou, Grases-Pintó, Massot-Cladera, Bernabeu, Knipping, Garssen, Bourdet-Sicard, Castell, Rodríguez-Lagunas, Collado and Pérez-Cano.

Déclaration de conflit d'intérêts

JG is part time employee/scientific advisor of Danone Nutricia Research. RB-S is employee of Danone Nutricia Research, and KK was also at time of the experiment. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.