α-Linolenic Acid Vesicles-Mediated Tau Internalization in Microglia.
Extracellualr Tau
Tau internalization
Tau microglia
α-Linolenic acid
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
9
7
2024
pubmed:
9
7
2024
entrez:
8
7
2024
Statut:
ppublish
Résumé
In Alzheimer's disease, the synaptic loss is prominent due to the accumulation of Amyloid βeta (Aβ) protein in synapses, which affect neurotransmission, and thus ultimately causes neuronal loss. Tau, a microtubule-associated protein, is a vital protein of intracellular neurofibrillary tangles (NFTs) in AD. Along with the accumulation of aberrant proteins, glial cells, mainly astrocytes and microglia, play a major role in impairing neuronal network. Microglia have the ability to phagocytose Tau and rerelease in exosomes, which causes further spreading of Tau. Reduction in exosome synthesis can reduce spreading of Tau. Modulating microglia to clear the extracellular Tau seeds by its imported degradation would resolve the disease condition in Alzheimer's disease. In this study, we have shown the ability of α-linolenic acid (ALA) to inhibit the Tau aggregation and modulate their internalization property in microglial cells.
Identifiants
pubmed: 38977593
doi: 10.1007/978-1-0716-3902-3_11
doi:
Substances chimiques
tau Proteins
0
alpha-Linolenic Acid
0RBV727H71
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-128Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
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